Publications by authors named "Anju Duva Pentiah"
Article Synopsis
- Previous research indicates that pulmonary hypertension is linked to higher mortality rates in patients with systolic heart failure (SHF), particularly after surgery or transplantation.
- This study analyzed 425 patients to identify key haemodynamic measurements that could help predict major cardiac events during a follow-up period.
- Findings suggest that baseline right atrial pressure, pulmonary vascular resistance, and mean pulmonary arterial pressure after an inotropic challenge are crucial indicators for assessing risk in patients with advanced SHF.
Background: Coronary artery disease (CAD) is the leading cause of systolic heart failure (HF). Cardiac magnetic resonance imaging (CMR) is a non-invasive technique that detects a myocardial infarction scar as subendocardial or transmural late gadolinium enhancement (st-LGE).
Aim: We sought to evaluate whether a lack of st-LGE could rule out CAD in new-onset systolic HF of unknown aetiology.
Background: Right ventricular (RV) systolic function is a powerful prognostic factor in patients with systolic heart failure. The accurate estimation of RV function remains difficult. The aim of the study was to determine the diagnostic accuracy of 2D-speckle tracking RV strain in patients with systolic heart failure, analyzing both free and posterolateral walls.
View Article and Find Full Text PDFAims: Mutations in PRKAG2, the gene encoding for the γ2 subunit of 5'-AMP-activated protein kinase (AMPK), are responsible for an autosomal dominant glycogenosis with a cardiac presentation, associating hypertrophic cardiomyopathy (HCM), ventricular pre-excitation (VPE), and progressive heart block. The aim of this study was to perform a retrospective time-to-event study of the clinical manifestations associated with PRKAG2 mutations.
Methods And Results: A cohort of 34 patients from 9 families was recruited between 2001 and 2010.
Mitochondrial dysfunction has been shown to be involved in the pathophysiology of arrhythmia, not only in inherited cardiomyopathy due to specific mutations in the mitochondrial DNA but also in acquired cardiomyopathy such as ischemic or diabetic cardiomyopathy. This article briefly discusses the basics of mitochondrial physiology and details the mechanisms generating arrhythmias due to mitochondrial dysfunction. The clinical spectrum of inherited and acquired cardiomyopathies associated with mitochondrial dysfunction is discussed followed by general aspects of the management of mitochondrial cardiomyopathy and related arrhythmia.
View Article and Find Full Text PDFArticle Synopsis
- Sildenafil treatment may benefit patients with left ventricular systolic dysfunction and severe pulmonary hypertension, traditionally seen as unsuitable for heart transplantation.
- In a study of 18 patients, significant improvements in heart function and reduced pulmonary resistance were observed after 8.7 months on sildenafil.
- The results suggest that sildenafil could enhance survival rates, particularly in patients who achieve lower pulmonary vascular resistance levels post-treatment.
Article Synopsis
- A study analyzed the long-term effects of β-blockade on 174 patients with left ventricular systolic dysfunction (LVSD) who improved their left ventricular ejection fraction (LVEF) to ≥45%.
- After a median follow-up of about 7.7 years, 74% of patients maintained their improved LVEF, but 26% experienced a decline, with several factors influencing the risk of deterioration, such as initial LVEF and heart rate.
- Overall, these patients showed good survival rates (90% at 5 years, 75% at 10 years), but those with declining LVEF faced a significantly higher cardiovascular mortality risk compared to those with stable