In-person vs mobile app facilitated life skills education to improve the mental health of internally displaced persons in Nigeria: protocol for the RESETTLE-IDPs cluster randomized hybrid type 2 effectiveness-implementation trial.

Background: Internally displaced persons (IDPs) in Nigeria face a high burden of mental health disorders, with limited access to evidence-based, culturally relevant interventions. Life skills education (LSE) is a promising approach to promote mental health and psychosocial well-being in humanitarian settings. This study aims to evaluate the effectiveness and implementation of a culturally adapted LSE program delivered through in-person and mobile platforms among IDPs in Northern Nigeria.

The costs and the potential allocation of costs of bouillon fortification: The cases of Nigeria, Senegal, and Burkina Faso.

Food and condiment fortification programs are needed to address micronutrient deficiencies and their health, developmental, and mortality consequences; but these programs are never free. Knowing program costs and their allocation across stakeholders is essential to design and manage effective, efficient, and sustainable programs. We developed 10-year hypothetical bouillon fortification program cost models for Nigeria, Senegal, and Burkina Faso that included start-up and operational costs for government and industry, as well as premix costs generated by an embedded premix cost calculator to allow for alternative premix formulas in cost calculations.

Voice, access, and ownership: enabling environments for nutrition advocacy in India and Nigeria.

What constitutes an enabling environment for nutrition advocacy in low- and middle-income countries? While a sizeable body of scholarship considers the enabling environment for nutrition policy, we focus specifically on the necessary conditions for advocacy. We argue that three factors-voice, access, and ownership-provide a useful lens into the advocacy enabling environment. These are operationalized, respectively, as the space to articulate and frame policy positions, entry points to interact with policy decision makers, and the existence of committed decision makers rather than those responding to pressures from external actors.

Adverse Drug Reactions and Changes in Haematological and Clinical Chemistry to Two ACTs among Nigerian Children with Acute Uncomplicated Malaria.

Background: Adverse drug reaction (ADR) is a global and frequently occurring medical emergency with increased cases of mortality annually. ADRs can occur with the use of all drugs including artemisinin-based combination therapy (ACTs) which are currently the treatment of choice for acute uncomplicated malaria globally. Numerous doses of ACTs are administered daily in malaria endemic areas.

Importance of Per2 in cardiac mitochondrial protection during stress.

During myocardial injury, inflammatory mediators and oxidative stress significantly increase to impair cardiac mitochondria. Emerging evidence has highlighted interplays between circadian protein-period 2 (Per2) and mitochondrial metabolism. However, besides circadian rhythm regulation, the direct role of Per2 in mitochondrial performance particularly following acute stress, remains unknown.

Mesenchymal Stem Cell-Derived Exosomal microRNAs in Cardiac Regeneration.

Mesenchymal stem cell (MSC)-based therapy is one of the most promising modalities for cardiac repair. Accumulated evidence suggests that the therapeutic value of MSCs is mainly attributable to exosomes. MSC-derived exosomes (MSC-Exos) replicate the beneficial effects of MSCs by regulating various cellular responses and signaling pathways implicated in cardiac regeneration and repair.

Unpacking the Social Constructs of Discrimination, Othering, and Belonging in Medical Schools.

Issue: Triggered by the lived experiences of the authors-one junior career, female, and black; the other senior career, male, and black-we provide a critical, sociological overview of the plight of racial/ethnic minority students in medical education. We analyze the concepts of categorization, othering, and belonging in medical education, which we use to shed light on the psychological and academic consequences of overgeneralizing social categories.

Evidence: The ability to categorize people into different social groups is a natural, subconscious phenomenon.

Efficacy and safety of pyronaridine-artesunate versus artemether-lumefantrine in the treatment of acute uncomplicated malaria in children in South-West Nigeria: an open-labelled randomized controlled trial.

Background: In Nigeria, declining responsiveness to artemether-lumefantrine (AL), the artemisinin-based combination therapy (ACT) of choice since 2005, has been reported. Pyronaridine-artesunate (PA) is a newer fixed-dose ACT recently prequalified by the WHO for the treatment of uncomplicated falciparum malaria. However, PA data from the Nigerian pediatric population is scarce.

Nutrition Capacity Assessment of Agriculture Extension Services in Nigeria.

Background: Achieving meaningful malnutrition reductions in Nigeria and other high-burden countries requires sustained improvements in diets, mediated through nutrition-sensitive agriculture and food systems. Yet, the capacity to design, plan, implement, and monitor such nutrition-sensitive systems is very limited, including within agricultural extension services delivery. Understanding existing capacity of actors required to implement nutrition change is crucial for effective capacity development.

Impact of traditional healers in the provision of mental health services in Nigeria.

Mental health remains one of the most overlooked issues in Nigeria. The burden posed by traditional healers in the provision of mental health services is becoming a public health concern in the country. This article presents a review of the present situation on the mental health service provision in Nigeria by traditional healers and highlights way forward actions for policy makers, government, and other stakeholders.

Sociodemographic factors associated with the use of insecticide treated nets among under-fives in Nigeria: Evidence from a national survey.

Insecticide treated nets (ITN) are effective in malaria prevention; however, they remain underutilized among children. A secondary analysis of the 2018 Nigeria-Demographic and Health Survey including logistic regression was conducted to determine factors influencing ITN use among under-fives (U5s). Overall, 22,954 (72.

Advocacy organizations and nutrition policy in Nigeria: identifying metrics for enhanced efficacy.

Advocacy organizations have played a significant role in the field of nutrition in recent years. However, why are some advocates viewed as more effective than others? This paper derives metrics for assessing advocacy efficacy by first drawing on key insights from the nutrition and public policy scholarship. A set of metrics is proposed to capture the constitutive elements of three concepts that often emerge as critical from that literature: organizational capacity, strong networks and external outreach.

Comparative evaluation of three histidine-rich Protein-2 based rapid diagnostic tests, microscopy and PCR for guiding malaria treatment in Ibadan, Southwest Nigeria.

Background: Malaria rapid diagnostic tests (mRDTs) are the preferred option for programmatic deployment.

Aims: There are numerous mRDTs on the Nigerian market and there is a need to guide practitioners on the relative performance of the commonly used brands of mRDT in Nigeria.

Subjects And Methods: The performance of three commonly used Histidine-Rich-Protein-2-based mRDTs (SD-Bioline™, Carestart™ and Paracheck-Pf™) against microscopy of Giemsa stained blood and polymerase chain reaction (PCR) was evaluated among 190 febrile under-5 children in Ibadan, Nigeria.

Coordinating Nigeria's micronutrient deficiency control programs is necessary to prevent deficiencies and toxicity risks.

Nigeria has an alarming prevalence of micronutrient deficiencies that has persisted over decades. National Micronutrient Deficiency Control (MNDC) guidelines describe several interventions to address the issue. This study identified and described currently implemented interventions, assessed coverage and coordination of the interventions, and considered the risk of overdosage and gaps.