Publications by authors named "Anjorin C"
Background: The initial sign of hypertensive heart disease (HHD) is left ventricular diastolic dysfunction (LVDD), which is caused by remodeling of the left ventricle and left atrium, resulting in impaired relaxation of the left ventricle. LVDD is also partly due to left ventricular hypertrophy (LVH). If left untreated, LVDD can progress to diastolic heart failure and systolic heart failure.
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- Systemic arterial hypertension is linked to cardiovascular issues, including aortic root dilation, which affects individuals regardless of age, gender, or body size; this study investigates its prevalence in untreated hypertensive patients.
- Conducted over two years, the research involved 300 treatment-naïve hypertensive patients and 300 matched healthy controls, using 2D echocardiography to measure the aortic root diameter.
- Results show that untreated hypertensive patients had significantly larger aortic root diameters compared to normotensive individuals, with a prevalence of aortic root dilation at 1.3% in the hypertensive group.
Although multifactorial in origin, one of the most impactful consequences of social isolation is an increase in breast cancer mortality. How this happens is unknown, but many studies have shown that social isolation increases circulating inflammatory cytokines and impairs mitochondrial metabolism. Using a preclinical Sprague Dawley rat model of estrogen receptor-positive breast cancer, we investigated whether social isolation impairs the response to tamoxifen therapy and increases the risk of tumors emerging from dormancy, and thus their recurrence.
View Article and Find Full Text PDFDigoxin toxicity has been implicated in all forms of cardiac arrhythmias with the notable exception of Mobitz II atrioventricular block, which is very rare. The manifestation is quite variable, ranging from being asymptomatic to gastrointestinal, cardiac, and neurologic symptoms. The manifestations can be protean in the elderly, the most vulnerable group, where degenerative cardiac conduction system diseases add another layer of intrigue by providing an intrinsic substrate for cardiac dysrhythmia.
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- * Out of 949 eligible adult patients, 82.40% had abnormalities related to LVT, with 8.85% (84 patients) actually diagnosed with LVT.
- * The most frequent causes of LVT were dilated cardiomyopathy (39.29%) and myocardial infarction (29.76%), while peripartum cardiomyopathy also resulted in multiple thrombi cases.