Discovery of urea-based pleuromutilin derivatives as potent gram-positive antibacterial agents.

There is an urgent need to discover new antibacterial drugs and provide new treatment options for clinical antimicrobial resistance (AMR) pathogen infections. Inspired by the structural insights from analyzing the co-crystal structure of lefamulin with the ribosomes of S. aureus, a series of novel pleuromutilin derivatives of phenylene sulfide incorporated with urea moiety were designed and synthesized.

Nigericin is effective against multidrug resistant gram-positive bacteria, persisters, and biofilms.

Multidrug-resistant (MDR) bacteria pose a significant clinical threat to human health, but the development of antibiotics cannot meet the urgent need for effective agents, especially those that can kill persisters and biofilms. Here, we reported that nigericin showed potent bactericidal activity against various clinical MDR Gram-positive bacteria, persisters and biofilms, with low frequencies of resistance development. Moreover, nigericin exhibited favorable efficacy in deep-seated mouse biofilm, murine skin and bloodstream infection models.

Bicyclomycin Activity against Multidrug-Resistant Gram-Negative Pathogens.

The growing prevalence of antimicrobial resistance poses a grave threat to human health. Among the most difficult bacterial infections to treat are those caused by multidrug-resistant (MDR) Gram-negative pathogens because few effective regimens are available. One approach to this problem is to find ways to increase the activity of old antimicrobials that had seen limited application.

Self-Powered Electrodeposition System for Sub-10-nm Silver Nanoparticles with High-Efficiency Antibacterial Activity.

Recently, silver nanoparticles (AgNPs) have been widely applied in sterilization due to their excellent antibacterial properties. However, AgNPs require rigorous storage conditions because their antibacterial performances are significantly affected by environmental conditions. Instant fabrication provides a remedy for this drawback.