Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, with oxidative stress recognized as a key pathogenic mechanisms. Oxidative stress disrupts intracellular dynamic- thiol/disulfide homeostasis (DTDH), potentially leading to disulfidptosis, a newly identified cell death mechanism. While studies suggest a link between DTDH and ASD, direct evidence implicating disulfidptosis in ASD pathogenesis remains limited.
View Article and Find Full Text PDFIn aquatic environments, antibiotics degrade into byproducts, potentially enhancing bacterial resistance. However, the specific mechanisms by which these byproducts induce bacterial resistance remain elusive. This study conducted experimental evolution experiments to explore how E.
View Article and Find Full Text PDFWe here investigate the expression of the mitochondrial carrier homolog 2 (MTCH2) and its potential function in castration-resistant prostate cancer (CRPC). Bioinformatic analyses reveal that MTCH2 overexpression is associated with critical clinical parameters of prostate cancer. Single-cell sequencing data indicate elevated MTCH2 expression in the prostate cancer epithelium.
View Article and Find Full Text PDFReplacing the sluggish anodic water oxidation reaction with the glucose oxidation reaction (GOR) offers an energy-saving strategy to obtain value-added products during the hydrogen production process. However, rational design of the GOR electrocatalyst with an explicit structure-property relationship remains a challenge. In this study, by using cobalt chalcogenides as model catalysts, we performed an in-depth study of the GOR catalytic mechanism of CoS and CoSe nanosheets.
View Article and Find Full Text PDFTalin-1 (TLN1), encoded by the TLN1 gene, is a focal adhesion-related protein capable of binding various proteins in the cytoskeleton. It is also expressed at high levels in many cancers wherein it influences cellular adhesion and the activation of integrins. TLN1 is also capable of promoting tumor cell invasivity, proliferation, and metastatic progression, in addition to being a relevant biomarker and therapeutic target in certain cancers.
View Article and Find Full Text PDFBackground: Abnormal sensory perception, particularly pain insensitivity (PAI), is a typical symptom of autism spectrum disorder (ASD). Despite the role of myelin metabolism in the regulation of pain perception, the mechanisms underlying ASD-related PAI remain unclear.
Methods: The pain-associated gene sphingosine-1-phosphate receptor 1 (S1PR1) was identified in ASD samples through bioinformatics analysis.
Developing electrocatalysts for the N reduction reaction (NRR) with high activity, high selectivity, and low cost is urgently required to enhance the NH yield rate. Based on first-principles calculations, we predict a series of new transition metal boride TMB (TM = Ti, V, Cr, Mn, Fe, and Co) monolayers and investigate their magnetoelectronic and electrocatalytic properties. The results reveal that VB and CoB favor ferromagnetic coupling, while TiB, CrB, MnB, and FeB display antiferromagnetic ordering.
View Article and Find Full Text PDFSubstituting thermodynamically favorable ethanol oxidation reaction (EOR) for oxygen evolution reaction (OER) engenders high-efficiency hydrogen production and generates high value-added products as well. However, the main obstacles have been the low activity and the absence of an explicit catalytic mechanism. Herein, a heterostructure composed of amorphous vanadium oxide and crystalline nickel nitride (VO-NiN) is developed.
View Article and Find Full Text PDFThe pervasive use of antibiotics has raised substantial environmental concerns, especially regarding their temporal and spatial distribution across diverse water systems. This study addressed the gap in comprehensive research on antibiotic contamination during different hydrological periods, focusing on the Jilin section of the Songliao Basin in Northeast China, an area with severe winter ice cover. The study examined the occurrence, distribution, influencing factors, and potential ecological risks of prevalent antibiotic contaminants.
View Article and Find Full Text PDFUnderstanding the structure-performance relationship is crucial for designing highly active electrocatalysts, yet this remains a challenge. Using MoS supported metal-nonmetal atom pairs (XTM@MoS, TM = Sc-Ni, and X = B, C, N, O, P, Se, Te, and S) for the hydrogen evolution reaction (HER) as an example, we successfully uncovered the structure-activity relationship with the help of density functional theory (DFT) calculations and integrated machine learning (ML) methods. An ML model based on random forest regression was used to predict the activity, and the trained model exhibited excellent performance with minimal error.
View Article and Find Full Text PDFTropomyosin (TPM) is an important regulatory protein that binds to actin in fine myofilaments, playing a crucial role in the regulation of muscle contraction. TPM3, as one of four tropomyosin genes, is notably prevalent in eukaryotic cells. Traditionally, abnormal gene expression of TPM3 has been exclusively associated with myopathy.
View Article and Find Full Text PDFMatrix metalloproteinases (MMPs) had a variety of subtypes, which may be related to tumor invasion and angiogenesis, and the polymorphisms from MMPs have been also associated with the susceptibility to a variety of tumors, including prostate cancer (PCa). However, previous studies have not systematically analyzed the association between MMP and prostate cancer, so we conducted systematic data collection and analyzed to evaluate the relationship among polymorphisms in MMPs and PCa susceptibility. We searched PubMed, Web of Science, Embase and Google Scholar for all papers published up to Apr 3rd, 2023, and systematically analyzed the relationship among MMP1-1607 2G/1G, MMP2-1306 T/C, MMP2-735 T/C, MMP7-181 G/A, MMP9-1562 T/C and PCa susceptibility using multiple comparative models and subgroup analyses.
View Article and Find Full Text PDFThe electrochemical nitrogen reduction reaction (eNRR) to NH has become an alternative to traditional NH production techniques, while developing NRR catalysts with high activity and high selectivity is of great importance. In this study, we systematically investigated the potentiality of dual transition metal (TM) atom anchored electrocatalysts, TMTM@CN (TM, TM = 3(4)d TM atoms), for the NRR through the first principles high-throughput screening method. A total of 78 TMTM@CN candidates were designed to evaluate their stability, catalytic activity, and selectivity for the NRR.
View Article and Find Full Text PDFO3-Type layered oxides are widely studied as cathodes for sodium-ion batteries (SIBs) due to their high theoretical capacities. However, their rate capability and durability are limited by tortuous Na diffusion channels and complicated phase evolution during Na extraction/insertion. Here we report our findings in unravelling the mechanism for dramatically enhancing the stability and rate capability of O3-NaNiMnSbO (NaNMS) by substitutional Sb doping, which can alter the coordination environment and chemical bonds of the transition metal (TM) ions in the structure, resulting in a more stable structure with wider Na transport channels.
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