Multifunctional Hollow Porous FeO@N-C Nanocomposites as Anodes of Lithium-Ion Battery, Adsorbents and Surface-Enhanced Raman Scattering Substrates.

At present, it is still a challenge to prepare multifunctional composite nanomaterials with simple composition and favorable structure. Here, multifunctional FeO@nitrogen-doped carbon (N-C) nanocomposites with hollow porous core-shell structure and significant electrochemical, adsorption and sensing performances were successfully synthesized through the hydrothermal method, polymer coating, then thermal annealing process in nitrogen (N) and lastly etching in hydrochloric acid (HCl). The morphologies and properties of the as-obtained FeO@N-C nanocomposites were markedly affected by the etching time of HCl.

In-situ fabrication of novel Au nanoclusters-Cu@sodium alginate/hyaluronic acid nanohybrid gels for cuproptosis enhanced photothermal/photodynamic/chemodynamic therapy via tumor microenvironment regulation.

Multimodal combined therapy (MCT) is an emerging avenue to eliminate tumor cells by the synergistic effect of various therapeutic methods. However, the complex tumor microenvironment (TME) is becoming the key barrier to the therapeutic effect of MCT due to the excessive existence of H ions, HO, and glutathione (GSH), the lack of O, and the relaxation of ferroptosis. To overcome these limitations, smart nanohybrid gels with excellent biocompatibility, stability and targeting function were prepared by using gold nanoclusters as cores and an in situ cross-linking composite gel of sodium alginate (SA)/hyaluronic acid (HA) as the shell.

Fabrication of porous ZnO/CoO nanohybrids for the application of surface enhanced Raman scattering.

With the growing use of various pesticides, it is important to develop facile and sensitive method to detect pesticides residues in food. Here, a semiconductor/magnetic hybrid material was used as surface enhanced Raman scattering (SERS) substrate to detect simulated residues. The representative sample of porous ZnO/CoO nano-cube was fabricated by pyrolysis and calcination of Zn-Co ZIF, successively.

Facile Synthesis of FeO@Au/PPy-DOX Nanoplatform with Enhanced Glutathione Depletion and Controllable Drug Delivery for Enhanced Cancer Therapeutic Efficacy.

The complex physiological environment and inherent self-healing function of tumors make it difficult to eliminate malignant tumors by single therapy. In order to enhance the efficacy of antitumor therapy, it is significant and challenging to realize multi-mode combination therapy by utilizing/improving the adverse factors of the tumor microenvironment (TME). In this study, a novel FeO@Au/PPy nanoplatform loaded with a chemotherapy drug (DOX) and responsive to TME, near-infrared (NIR) laser and magnetic field was designed for the combination enhancement of eliminating the tumor.

Self-assembled AuCu/Au NCs@liposome tumor nanotheranostics with PT/fluorescence imaging-guided synergetic PTT/PDT.

Exploring and developing a new type of nanoplatform with diagnosis and treatment to effectively cure tumors and reduce side effects has become a hot spot for researchers and is of great significance. Herein, a cancer theranostic nanoplatform with dual-imaging, dual-phototherapy and laser-responsiveness to tumor microenvironment was successfully assembled by liposome (Lip) co-loaded with oil-soluble AuCu nanoclusters (NCs) and water-soluble Au NCs via a simple film hydration method and subsequent extraction process. The prepared AuCu/Au@Lip nanoplatform with core-shell structure and about 50 nm of uniform sphere shape presented highly biocompatible, stability and passive targeting due to the enhanced permeability and retention (EPR) effect.

An effective NIR laser/tumor-microenvironment co-responsive cancer theranostic nanoplatform with multi-modal imaging and therapies.

Cancer is still a major threat to human health at present. Developing new types of integrated nanoplatforms for the accurate diagnosis and effective treatment of cancer is very significant. Herein, an intelligent dual-stage core-shell cancer theranostic nanoplatform (Fe3+@Au1Ag24@PbP) with NIR laser/tumor-microenvironment (TME) co-responsiveness and multi-modal imaging-therapy was successfully prepared, which was composed of the precisely structured oil-soluble Au1Ag24 nanoclusters (NCs) and Fe3+ ions easily assembled within the oil and aqueous phases of the polyethylene glycol (PEG) block grafted polyketal (PK) copolymer (PK-b-PEG, PbP) vesicles, respectively.

4-in-1 FeO/g-CN@PPy-DOX nanocomposites: Magnetic targeting guided trimode combinatorial chemotherapy/PDT/PTT for cancer.

At present, cancer has become a major disease threatening human health worldwide. Therefore, developing targeting guided multimode synergetic therapy has become one of the hot spots in current antitumor research and is also a great challenge. Herein, a new FeO/g-CN@PPy-DOX nanocomposite containing magnetic iron oxide (FeO) nanoparticles (NPs), lamellar structure of graphite-like carbon nitride (g-CN) and polypyrrole (PPy) shell with the loaded anti-tumor drug doxorubicin hydrochloride (DOX) was designed and prepared.

Structurally accurate lipophilic PtAg nanoclusters based cancer theranostic micelles for dual-targeting/aggregation enhanced fluorescence imaging and photothermal/photodynamic therapies.

Theranostics including imaging and therapy has become an advanced trend for cancer treatment. It is of great significance to develop new theranostics agent for precision medicine research. In this regard, structurally precise metal nanoclusters (NCs) with ultra-small diameter and potential theranostic functions are no doubt to be a priority.

A structurally precise AgAu nanocluster based cancer theranostic platform with tri-targeting/ O-generation/aggregation enhanced fluorescence imaging/photothermal-photodynamic therapies.

The photothermal and photodynamic performances of structurally precise oil-soluble AgxAu25-x (x ≤ 13) nanoclusters were first explored and they were solubilized into new assemblies to form a versatile cancer theranostic platform with tri-targeting/in situ O2-generation/aggregation enhanced fluorescence imaging/photothermal-photodynamic therapy effects, which will provide an important reference for precision theranostics at the atomic level in future.

Effective photodynamic therapy of polymer hydrogel on tumor cells prepared using methylene blue sensitized mesoporous titania nanocrystal.

A novel hydrogel shell on cancer cells was prepared via in situ photopolymerization of polyethyleneglycol diacrylate (PEGDA) using methylene blue (MB) sensitized mesoporous titania nanocrystal for effective photodynamic therapy (PDT). TiO in this system served as an effective photosensitizer and initiator for the formation of hydrogel, also can protect the MB from being degraded into an inactive form. While MB was used as a significant photosensitive additive to improve the photochemistry effects of TiO and widen its optical response area to near infrared region (660-900 nm).

Developing cysteamine-modified SERS substrate for detection of acidic pigment with weak surface affinity.

In this paper, we developed cysteamine-modified surface-enhanced Raman scattering (SERS) substrate for detecting detect trace amount of acidic pigment that shows weak affinity with gold nanoparticles (Au NPs). To realize sensitive and reproducible detection of pigment with weak affinity, the SERS substrate was prepared by attaching cysteamine (CA) to the Au NPs, the acidic pigment molecule could rapidly reached to the surface of Au NPs because of the formation of multi‑hydrogen-bond and electrostatic interaction between the pigment and CA molecule. The proposed method allowed us to detect five kinds of acidic pigment with a limit of 1.

B, N Co-Doped Three-Dimensional Carbon Aerogels with Excellent Electrochemical Performance for the Oxygen Reduction Reaction.

Herein, an ordinary and mass-production approach is reported to synthesize boron (B) and nitrogen (N) co-doped three-dimensional (3D) carbon aerogels (CA) by using glucose and borax as the raw materials by a simple hydrothermal method and then carbonization in NH atmosphere. The porous material (BN-CA-900) possesses a large specific surface area (1032 m  g ) and high contents of doped pyridinic N and graphitic N. The onset potential (0.

Construction and synergistic anticancer efficacy of magnetic targeting cabbage-like FeO@MoS@ZnO drug carriers.

A novel cabbage-like FeO@MoS@ZnO nanocomposite was successfully fabricated through a facile method. The as-prepared nanocomposite exhibited a saturation magnetization of 45 emu g as well as possessed a massive pore structure and large surface area, leading to a high DOX loading capacity of 68.14 μg mg; it could effectively deliver drugs to tumor lesion sites under the action of magnetic targeting.

Improved fluorescence imaging and synergistic anticancer phototherapy of hydrosoluble gold nanoclusters assisted by a novel two-level mesoporous canal structured silica nanocarrier.

A novel integrated system composed of hydrosoluble gold nanoclusters (AuNCs), two-level mesoporous canal silica, gelatin and folic acid was for the first time designed and synthesized, which could conquer poor stability of AuNCs and shows aggregation-enhanced fluorescence imaging, cancer cell-specific targeting, and synergistic photothermal/photodynamic therapies for the goal of personalized nanotheranostics.

Litchi-like FeO@Fe-MOF capped with HAp gatekeepers for pH-triggered drug release and anticancer effect.

A novel litchi-like porous composite composed of a magnetic core, a tunable metal-organic framework (MOF) shell and a pH-sensitive hydroxyapatite (HAp) gatekeeper was successfully fabricated in this work. The anticancer drug doxorubicin (DOX) was effectively loaded on the FeO@Fe-MOF@HAp nanocomposite with a loading capacity of 75.38 mg g.

Photosensitive multifunctional poly(vinyl alcohol) micelles for enhanced antitumor effect.

Polyvinyl alcohol (PVA) micelles were firstly synthesized by using hemin molecules as novel crosslinked bridges (PVA-H crosslinked micelles). On one hand, the crosslinked micelles can allow high stability against extensive dilution (1800-fold) to reduce side-effects; On the other hand, the bridges not only can destruct by means of laser irradiation (405nm, 200mw), but also can induce the production of singlet oxygen (O) and the release of 5-fluorouracil (5FU) (i.e.

A novel composite hydrogel initiated by Spinacia oleracea L. extract on Hela cells for localized photodynamic therapy.

In this study, the poly (ethylene glycol) double acrylates (PEGDA) was first initiated by Spinacia oleracea L. extract (SOLE) to in situ form a polymer hydrogel shell on Hela cells with near infra-red irradiation. The SOLE was also a natural photosensitizer for photodynamic therapy of tumor.

RGO/AuNR/HA-5FU nanocomposite with multi-stage release behavior and efficient antitumor activity for synergistic therapy.

A reduced graphene oxide (RGO)/gold nanorod (AuNR)/hydroxyapatite (HA) nanocomposite was designed and successfully synthesized for the first time. An anticancer drug, 5-fluorouracil (5FU), was chosen as a model drug to be loaded in RGO/AuNR/HA. The fabricated RGO/AuNR/HA-5FU showed robust, selective targeting and penetrating efficiency against HeLa cells due to the good compatibility and nontoxicity of HA, and showed excellent synergetic antitumor effects through combined chemotherapy (CT) by 5FU and photothermal therapy (PTT) by both RGO and AuNRs under near-infrared (NIR) laser irradiation.

Graphene oxide and creatine phosphate disodium dual template-directed synthesis of GO/hydroxyapatite and its application in drug delivery.

In this study, graphene oxide and creatine phosphate disodium acted as dual template and was employed to synthesize graphene oxide (GO)/hydroxyapatite (HA) hybrids as drug carriers. In the rapid preparation of GO/HA hybrids, creatine phosphate disodium salt (CPDS) severed as a phosphorus source and graphene oxide acted as a template in aqueous solution. The effects of the reaction temperature, time and pH value of the aqueous solution on the morphology of the product were investigated.

A novel porous aspirin-loaded (GO/CTS-HA)n nanocomposite films: Synthesis and multifunction for bone tissue engineering.

A novel porous graphene oxide (GO)/chitosan (CTS)-hydroxyapatite (HA) nanocomposite film was successfully prepared for the first time by combining layer-by-layer (LBL) assembly technology with biomimetic mineralization method. The LBL technology was used to control the thickness of film as well as induce the biomimetic mineralization of biocompatible HA. The obtained (GO/CTS-HA)n film provided ideal platform for the proliferation of mouse mesenchymal stem cells (mMSCs).

Nitrogen-doped nanoporous carbon derived from waste pomelo peel as a metal-free electrocatalyst for the oxygen reduction reaction.

The development of a new catalyst for the low-cost, environmentally friendly and highly efficient oxygen reduction reaction (ORR) is important for the commercialization of fuel cells. Herein, a smart strategy was proposed for the preparation of a novel nitrogen-doped nanoporous carbon (N-PC) using resource-rich pomelo peel, a type of waste, as starting material. The typical product (N-PC-1000) possesses a high BET surface area (up to 1444.

An ordered and porous N-doped carbon dot-sensitized Bi2O3 inverse opal with enhanced photoelectrochemical performance and photocatalytic activity.

A novel ordered porous Bi2O3 inverse opal structure (IOS) was prepared using a polystyrene (PS) photonic crystal as the template for the first time. Nitrogen-doped carbon dots (N-CDs) were chosen to sensitize the as-prepared Bi2O3 IOS for improving photoelectrochemical performance and photocatalytic activity. The photocurrent density of the fabricated N-CDs/Bi2O3 IOS with favorable visible light absorption properties can achieve 0.

Reduced Graphene Oxide/Amaranth Extract/AuNPs Composite Hydrogel on Tumor Cells as Integrated Platform for Localized and Multiple Synergistic Therapy.

Integration of multimodal treatment strategies combined with localized therapy to enhance antitumor efficacy and reduce side effects is still a challenge. Herein, a novel composite hydrogel containing rGO, amaranth extract (AE) and gold nanoparticles (AuNPs) was prepared by using AE as both reductant and cross-linking agent. The chlorophyll derivatives in AE were also employed as a photodynamic therapy drug.

Nacre-like calcium carbonate controlled by ionic liquid/graphene oxide composite template.

Nacre-like calcium carbonate nanostructures have been mediated by an ionic liquid (IL)-graphene oxide (GO) composite template. The resultant crystals were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy, and X-ray powder diffractometry (XRD). The results showed that either 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM]BF4) or graphene oxide can act as a soft template for calcium carbonate formation with unusual morphologies.

Self-healable hydrogel on tumor cell as drug delivery system for localized and effective therapy.

A self-healable chitosan(CS)/polyvinyl alcohol (PVA) hydrogel as an injectable drug carrier was first prepared in situ on tumor cells for effective and localized therapy. PVA molecules have a synergistic effect on the formation and maintenance of 3D network conformation of hydrogel. The hydrogel shows good biocompatibility and could be easily and rapidly formed.