Publications by authors named "Anjana Soundararajan"
Article Synopsis
- Cell-free DNA (cfDNA) is considered a promising biomarker for cancer, as it reflects the tumor's genetic profile and can be monitored easily over time.
- A study examined cfDNA from 15 patients with metastatic castration-resistant prostate cancer before and after chemotherapy, finding that long cfDNA fragments changed dynamically following treatment.
- The results show that in some patients, these changes in cfDNA levels occurred quickly post-infusion, indicating that cfDNA could be a useful tool for tracking immediate treatment effects.
The androgen receptor (AR) pathway plays a central role in prostate cancer (PCa) growth and progression and is a validated therapeutic target. In response to ligand binding AR translocates to the nucleus, though the molecular mechanism is not well understood. We therefore developed multimodal Image Correlation Spectroscopy (mICS) to measure anisotropic molecular motion across a live cell.
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