Publications by authors named "Anjana Soorajkumar"
Article Synopsis
- The 15q11-q13 genetic region is crucial for neurodevelopment and exhibits genomic imprinting, where gene expression differs depending on whether the gene is inherited from the mother or the father.
- Neurodevelopmental disorders like Prader-Willi syndrome and Angelman syndrome arise from the absence of specific genes in this region due to imprinting errors.
- A genomic study was conducted on a Bangladeshi population to identify pathogenic variants in this region, leading to in-depth clinical evaluations of individuals with suspected neurodevelopmental disorders.
Duchenne muscular dystrophy (DMD) is a severe rare neuromuscular disorder caused by mutations in the X-linked dystrophin gene. Several mutations have been identified, yet the full mutational spectrum, and their phenotypic consequences, will require genotyping across different populations. To this end, we undertook the first detailed genotype and phenotype characterization of DMD in the Bangladeshi population.
View Article and Find Full Text PDFShort linear motifs (SLiMs) are short linear sequences that can mediate protein-protein interaction. Mimicking eukaryotic SLiMs to compete with extra- or intracellular binding partners, or to sequester host proteins is the crucial strategy of viruses to pervert the host system. Evolved proteins in viruses facilitate minimal protein-protein interactions that significantly affect intracellular signaling networks.
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