Immunohistochemical Localization of Epithelial Mesenchymal Transition Markers in Cyclosporine A Induced Gingival Overgrowth.

Introduction: Cyclosporine, an immunosuppressive agent used in the management of renal transplant patients is known to produce Drug Induced Gingival Overgrowth (DIGO) as a side effect. Several mechanisms have been elucidated to understand the pathogenesis of DIGO. Recently, epithelial mesenchymal transition has been proposed as a mechanism underlying fibrosis of various organs.

Management of a rare case of peripheral squamous odontogenic tumor of the gingiva.

Odontogenic tumors (OTs) arising from the periodontium are quite rare. Squamous OT (SOT) is one such neoplasm which has an exceedingly rare occurrence. According to the literature, there have been very few reported cases of SOT with a very small percentage involving the gingiva.

Spindle cell carcinoma of the gingiva: A rare occurrence.

Of the many neoplasms known, squamous cell carcinoma (SCC) is the most common to affect the oral cavity. Spindle cell carcinoma (SpCC) is considered a rare high malignant variant of SCC occurring predominantly in the upper aerodigestive tract. Soft-tissue spindle cell neoplasms are quite uncommon in the oral cavity reportedly accounting for lesser than 1% of all tumors in the oral region.