Analysis of Gene Polymorphism in Skeletal Class-III Malocclusion Due to Mandibular Prognathism.

 Mandibular prognathism (MP) is a craniofacial deformity resulting from the combined effects of environmental and genetic factors. Although various linkage and genome-wide association studies for mandibular prognathism have identified multiple strongly associated regions and genes, the causal genes and variants responsible for the deformity remained ambiguous.  This research work was aimed to study the association between polymorphism rs10850110 of the gene and skeletal class-III malocclusion in our local population.

Genetics of Dentofacial and Orthodontic Abnormalities.

The development of craniofacial complex and dental structures is a complex and delicate process guided by specific genetic mechanisms. Genetic and environmental factors can influence the execution of these mechanisms and result in abnormalities. An insight into the mechanisms and genes involved in the development of orofacial and dental structures has gradually gained by pedigree analysis of families and twin studies as well as experimental studies on vertebrate models.