Publications by authors named "Anjali Verma"

Introduction: Celiac disease (CD) in children can be associated with Type 1 Diabetes Mellitus (T1DM) as both share autoimmune etiology. Mainstay of treatment in celiac disease is total avoidance of gluten in diet whereas treatment in child with both the diseases will be Insulin therapy, exercise along with gluten free diet (GFD). There is dearth of literature regarding adherence to GFD and barriers for children with both T1DM and CD.

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  • - Loss-of-function studies reveal that T cell factor-1 (TCF1) is crucial for T cell development in the thymus, and its expression is regulated by E box DNA binding proteins independently of Notch signaling.
  • - Systematic analysis of five E protein binding elements (EPE1-5) shows that EPE3 is vital for αβ T cell development, while EPE1, 3, and 5 are important for γδ T cell maturation and fate decisions.
  • - The balanced expression of TCF1, influenced by specific EPEs, is essential for generating the appropriate number of T cells in the thymus.
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Long non-coding RNAs (lncRNAs) are long RNA transcripts with length >200 nucleotides that do not encode proteins. They play a crucial role in regulating HIV-1 infection, yet their involvement in myeloid cells remains underexplored. Myeloid cells are susceptible to HIV infection and contribute substantially to the latent HIV reservoir.

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  • Researchers developed a transformation system using Agrobacterium to study gene function in grass pea (Lathyrus sativus), which is known for its protein-rich seeds but has limitations due to a neurotoxin present in the plant.
  • They focused on the role of an enzyme called oxalyl-CoA synthetase (OCS) in oxalate metabolism, which is crucial for understanding β-ODAP production, the neurotoxin linked to health issues.
  • Their experiments demonstrated that modifying the LsOCS gene can help manage oxalate levels without increasing toxic compound levels, suggesting that this genome editing approach can efficiently enhance desirable traits in grass pea cultivation.
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Background: The presence of latent HIV reservoirs continues to be the biggest obstacle to achieving an HIV cure. Thus, long non-coding RNAs (lncRNAs) may serve as the preferred targets for HIV latency reversal. The goal of the study was to identify prospective lncRNAs for subsequent in vitro molecular and functional characterization.

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Aim: The post-operative sequelae of third molar surgical extractions need to be controlled in order to reduce patient morbidity. Dexamethasone is a well-researched drug which has established its merit as an anti-inflammatory agent. The aim of this randomized clinical study was to compare the patient-centric outcomes after pre-emptive intramuscular injection of dexamethasone into the masseter and deltoid, respectively.

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Tumours of the adrenal cortex are most commonly seen in adults but rare in children. The clinical manifestations depend on the age and sex of patients; about two-thirds of the cases virilisation is the predominant presentation, whereas many presents with both virilisation and cushingoid features. Diagnosis is confirmed by hormonal evaluation and radiological investigations.

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T-box riboswitches are noncoding RNA elements involved in genetic regulation of most Gram-positive bacteria. They regulate amino acid metabolism by assessing the aminoacylation status of tRNA, subsequently affecting the transcription or translation of downstream amino acid metabolism-related genes. Here we present single-molecule FRET studies of the Mycobacterium tuberculosis IleS T-box riboswitch, a paradigmatic translational T-box.

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The current analytical study is dedicated to the boundary layer regime where heat and mass transfer rates are ruled by natural convection. A rectangular enclosure filled with a combination of an arbitrary buoyancy ratio has an Oseen-linear solution, and the position of Beavers and Joseph's condition is employed at the porous fluid interface. Thermal radiation's interaction with a porous lining influences overall heat transfer in a system.

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  • This study focuses on using advanced imaging techniques to diagnose mucolipidosis type IV (ML-IV) and introduces a new genetic variant in siblings.* -
  • Two cases are presented: a 4-year-old boy with significant corneal and developmental issues linked to hyperreflective epithelial changes observed via anterior segment optical coherence tomography (AS-OCT), and his younger sibling with a milder form of the same condition.* -
  • The findings underscore the importance of AS-OCT in early detection of ML-IV and the need for genetic counseling for affected families, highlighting the diverse clinical presentations of the disorder.*
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  • - The microbiome, particularly the gut and lung microbial communities, plays a vital role in immune system development and overall health, with interactions known as the "gut-lung axis."
  • - Dysbiosis, or imbalances in gut microbiota, can negatively impact lung health and contribute to respiratory diseases by influencing inflammatory responses in lung immune cells.
  • - Modifying gut microbiome composition through probiotics, prebiotics, or fecal microbiota transplantation holds potential for new treatments to enhance lung immunity and manage diseases like SARS-CoV-2.
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Mice with cardiac-specific overexpression of adenylyl cyclase (AC) type 8 (TG) are under a constant state of severe myocardial stress. They have a remarkable ability to adapt to this stress, but they eventually develop accelerated cardiac aging and experience reduced longevity. We have previously demonstrated through bioinformatics that constitutive adenylyl cyclase activation in TG mice is associated with the activation of inflammation-related signaling pathways.

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Objective: Type 1 diabetes (T1D) occurs because of islet infiltration by autoreactive immune cells leading to destruction of beta cells and it is becoming evident that beta cell dysfunction partakes in this process. We previously reported that genetic deletion and pharmacological antagonism of the cannabinoid 1 receptor (CB1) in mice improves insulin synthesis and secretion, upregulates glucose sensing machinery, favors beta cell survival by reducing apoptosis, and enhances beta cell proliferation. Moreover, beta cell specific deletion of CB1 protected mice fed a high fat high sugar diet against islet inflammation and beta cell dysfunction.

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Time-dependent single-molecule experiments contain rich kinetic information about the functional dynamics of biomolecules. A key step in extracting this information is the application of kinetic models, such as hidden Markov models (HMMs), which characterize the molecular mechanism governing the experimental system. Unfortunately, researchers rarely know the physicochemical details of this molecular mechanism a priori, which raises questions about how to select the most appropriate kinetic model for a given single-molecule data set and what consequences arise if the wrong model is chosen.

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  • Primary intraosseous carcinoma (PIOC) of the jaw is a rare type of cancer that originates from the lining of odontogenic cysts or from dental tissue without connecting to the mouth's mucosa.
  • A case study of a 35-year-old male diagnosed with PIOC developing from an odontogenic keratocyst (OKC) revealed specific histopathological characteristics such as a cystic lesion with unique epithelial features.
  • The surgical approach involved extensive incisions and cavity creation to effectively treat the condition, emphasizing the need for awareness of PIOC's features for accurate diagnosis and timely intervention in cases of jaw tumors.
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A complex metabolic condition referred to as Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR) and decreased insulin production. Obesity, dyslipidemia, hypertension, and chronic inflammation are just a few of the cardiometabolic illnesses that people with T2DM are more likely to acquire and results in cardiovascular issues. It is essential to comprehend the mechanistic insights into these risk variables in order to prevent and manage cardiovascular problems in T2DM effectively.

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Humans are colonized by large number of microorganisms-bacteria, fungi, and viruses. The overall genome of entire viruses that either lives on or inside the human body makes up the human virome and is indeed an essential fraction of the human metagenome. Humans are constantly exposed to viruses as they are ubiquitously present on earth.

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Pomegranate peel, derived from the processing of . (pomegranate), has traditionally been considered agricultural waste. However, recent studies have revealed its potential as a rich source of bioactive compounds with diverse pharmacological effects.

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Background: Mice with cardiac-specific overexpression of adenylyl cyclase (AC) type 8 (TG ) are under a constant state of severe myocardial stress. They have a remarkable ability to adapt to this stress, but they eventually develop accelerated cardiac aging and experience reduced longevity.

Results: Here we demonstrate that activation of ACVIII in cardiomyocytes results in cell-autonomous RelA-mediated NF-κB signaling.

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A critical step in data analysis for many different types of experiments is the identification of features with theoretically defined shapes in -dimensional datasets; examples of this process include finding peaks in multi-dimensional molecular spectra or emitters in fluorescence microscopy images. Identifying such features involves determining if the overall shape of the data is consistent with an expected shape; however, it is generally unclear how to quantitatively make this determination. In practice, many analysis methods employ subjective, heuristic approaches, which complicates the validation of any ensuing results-especially as the amount and dimensionality of the data increase.

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Time-dependent single-molecule experiments contain rich kinetic information about the functional dynamics of biomolecules. A key step in extracting this information is the application of kinetic models, such as hidden Markov models (HMMs), which characterize the molecular mechanism governing the experimental system. Unfortunately, researchers rarely know the physico-chemical details of this molecular mechanism which raises questions about how to select the most appropriate kinetic model for a given single-molecule dataset and what consequences arise if the wrong model is chosen.

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Dental extraction in hemophiliacs can be complicated by perilous bleeding. Although developments in local hemostatics and factor replacement have made outpatient extraction feasible, there is no standard protocol for preventing hemorrhagic exigency. Low-level laser therapy (LLLT) has firmly established role in hemostasis due to its ability to seal vessels, but this function has not been conclusively established in hemophiliac patients.

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Purpose: The literature is replete with various approaches for the temporomandibular joint (TMJ), each with its own distinct advantages and disadvantages. None of these approaches, however, have been associated with superior operative outcomes. The purpose of this study was to measure the efficacy of three operative approaches to TMJ, namely superficial, subfascial, and deep subfascial approaches.

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