Role of MMP-2 and its inhibitor TIMP-2 as biomarkers for susceptibility to systemic lupus erythematosus.

To investigate the possible association between (-1575 G/A, -1306 C/T) and its inhibitor (-418 G/C) functional polymorphisms with development of severity in systemic lupus erythematosus (SLE) patients. 150 SLE patients and matched healthy controls were recruited. Polymorphisms were detected by PCR-RFLP and serum levels by ELISA.

Role of polymorphisms in MMP-9 and TIMP-1 as biomarkers for susceptibility to systemic lupus erythematosus patients.

Aim: To investigate the possible association between MMP-9 (-1562 C/T) and TIMP-1 (372 T/C) polymorphism and inflammatory markers with disease activity in systemic lupus erythematosus (SLE) patients.

Materials & Methods: 150 SLE patients were recruited. Disease severity was assessed by SLEDAI (SLE disease activity index).