Depression among inmates of Gandaki Province, Nepal: a cross-sectional study.

Introduction: Depression is a pervasive mental health condition that affects individuals across various demographic categories, including imprisoned adults. The prevalence of mental health problems among inmates worldwide is considerably higher than in the general population, and it is estimated that 11% of inmates have significant mental disorders, such as anxiety and depression. This study aimed to find out the prevalence of depression and factors associated with it among the prisoners of Gandaki Province, Nepal.

Fe-induced luminescence quenching in carbon dots - mechanism unveiled.

Carbon dot (CD)-based fluorimetric sensors have attracted immense attention for the detection of metal ions. Among the available works in this direction, more than 70% of the studies reported the detection of Fe through luminescence quenching. Ferric ions are significant species from environmental and biological point of view.

-Phenylenediamine-derived carbon nanodots for probing solvent interactions.

Carbon nanodots, the luminescent nanoparticles of carbon with size restriction below 10 nm, have attracted inordinate attention in materials science due to their widespread applications in optoelectronic and biological fields. Low toxicity and facile synthesis pathways render them favourites in the above-mentioned areas in the context of green chemistry. This work presents fine applications of -phenylenediamine-derived carbon nanodots (PD-CNDs) achieved a facile one-pot hydrothermal method.

Comparative assessment of implementation of Cigarette and Other Tobacco Products Act in three States of India: A pre-post study.

Background Objectives: The Cigarette and Other Tobacco Products Act (COTPA) limits the sale of tobacco products, promotion and advertising and packaging of tobacco products in India. Periodic monitoring of the level of compliance with all sections of COTPA is obligatory to assess the effectiveness of the act.

Methods: This pre-post study aimed to assess the change in the level of compliance with different sections of COTPA in selected States.

RNA-Seq based global transcriptome analysis of rice unravels the key players associated with brown planthopper resistance.

Rice production is adversely affected by biotic and abiotic stresses. Among the biotic stresses, brown planthopper (BPH) majorly affects the rice yield. Comprehending the genome and candidate players is essential for the resistance to BPH.

Spindlin docking protein (SPIN.DOC) interaction with SPIN1 (a histone code reader) regulates Wnt signaling.

Indepth studies of protein-protein interactions are essential for discovering the molecular mechanisms and the biological context of protein functions. Even though previous study on the purification of SPIN1 interacting protein complex has shown Spindlin docking protein (SPIN.DOC) as the most abundant interacting protein partner; the study on the molecular function of SPIN.

Metformin-loaded BSA nanoparticles in cancer therapy: a new perspective for an old antidiabetic drug.

Clinical and experimental data suggest that there is a strong association between type II diabetic mellitus and pancreatic cancer. The present study focuses on exploring the anticancer and antidiabetic properties of metformin-loaded bovine serum albumin nanoparticles (BSA NPs) on (MiaPaCa-2) pancreatic carcinoma cell lines. Albumin nanoparticles were synthesized using coacervation method and the average size of the particles was found to be 97 nm.

Recent trends in drug delivery system using protein nanoparticles.

Engineered nanoparticles that can facilitate drug formulation and passively target tumours have been under extensive research in recent years. These successes have driven a new wave of significant innovation in the generation of advanced particles. The fate and transport of diagnostic nanoparticles would significantly depend on nonselective drug delivery, and hence the use of high drug dosage is implemented.

BSA nanoparticle loaded atorvastatin calcium--a new facet for an old drug.

Background: Currently, the discovery of effective chemotherapeutic agents poses a major challenge to the field of cancer biology. The present study focuses on enhancing the therapeutic and anti cancer properties of atorvastatin calcium loaded BSA (ATV-BSA) nanoparticles in vitro.

Methodology/results: BSA-ATV nanoparticles were prepared using desolvation technique.

Mechanistic insights into interaction of humic acid with silver nanoparticles.

Humic acid (HA) is one of the major components of the natural organic matter present in the environment that alters the fate and behavior of silver nanoparticles (Ag NPs). Transformation of Ag NPs happens upon interaction with HA, thereby, changing both physical and chemical properties. Fluorescence spectroscopy and scanning electron microscopy (SEM) were used to analyze the interaction of Ag NPs with HA.

Distinctive effects of nano-sized permethrin in the environment.

Pesticides are an essential tool in integrated pest management. Nanopermethrin was prepared by solvent evaporation from an oil-in-water volatile microemulsion. The efficacy of the formulated nanopermethrin was tested against Aedes aegypti and the results compared to those of regular, microparticular permethrin.

Biodegradable polymer based encapsulation of neem oil nanoemulsion for controlled release of Aza-A.

Azadirachtin a biological compound found in neem have medicinal and pesticidal properties. The present work reports on the encapsulation of neem oil nanoemulsion using sodium alginate (Na-Alg) by cross linking with glutaraldehyde. Starch and polyethylene glycol (PEG) were used as coating agents for smooth surface of beads.

Neem oil (Azadirachta indica) nanoemulsion--a potent larvicidal agent against Culex quinquefasciatus.

Background: Nanoemulsion composed of neem oil and non-ionic surfactant Tween 20, with a mean droplet size ranging from 31.03 to 251.43 nm, was formulated for various concentrations of the oil and surfactant.

Formulation of water-dispersible nanopermethrin for larvicidal applications.

The formulation of water dispersible nanopermethrin was investigated for its larvicidal property. Nanopermethrin was prepared using solvent evaporation of oil in water microemulsion, which was obtained by mixing an organic and aqueous phase. The mean particle size of nanodispersion in water was 151 ± 27 nm.

Effect of L-arginine on systemic and renal haemodynamics in salt-sensitive patients with essential hypertension.

In response to a high sodium (Na+) intake, salt-sensitive patients with hypertension retain more Na+ and manifest a greater rise in arterial pressure than salt-resistant patients. Because there is limited information regarding the role of nitric oxide (NO) in salt-sensitivity we examined the effects of L-arginine (500 mg/kg, i.v.