Publications by authors named "Anja-Kristin Siegel"
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Synopsis of recent research by authors named "Anja-Kristin Siegel"
- Anja-Kristin Siegel's research primarily focuses on the genetic and physiological mechanisms behind salt-sensitive hypertension, particularly utilizing Dahl salt-sensitive (SS) and spontaneously hypertensive (SHR) rat models to investigate organ damage from high-salt diets.
- Her studies have identified several quantitative trait loci (QTL) linked to protective effects against salt-induced organ damage, revealing distinct genetic characteristics between salt-sensitive and salt-resistant strains that influence the severity of hypertension and renal injury.
- Findings from her work demonstrate that early-onset albuminuria and the progression of vascular and cardiac hypertrophy in salt-sensitive individuals are polygenic traits, independent of salt loading, highlighting the complexity of genetic factors involved in hypertension and renal health.
