Publications by authors named "Anja S Frost"

Given the unremitting obstacles to effectively screen for and treat ovarian cancer (OC), prevention is a necessary countermeasure. The recent discovery of the fallopian tube as the origin of the most common and deadly type of OC, high grade serous cancer (HGSC), makes prevention through salpingectomy possible (Madsen et al., 2015).

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Background: Postoperative pain continues to be an undermanaged part of the surgical experience. Multimodal analgesia has been adopted in response to the opioid epidemic, but opioid prescribing practices remain high after minimally invasive hysterectomy. Novel adjuvant opioid-sparing analgesia to optimize acute postoperative pain control is crucial in preventing chronic pain and minimizing opioid usage.

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Objective: To identify patient, perioperative, and hospital factors that drive total hospital charges for benign hysterectomy.

Methods: The authors conducted a retrospective cohort study between July 2014 and February 2019 at five academic and community hospitals within an integrated healthcare system in the state of Maryland with a Global Budget Revenue methodology for hospital charges. Predictor variables included patient, perioperative and hospital characteristics.

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Background And Objectives: To evaluate postoperative opioid use after benign minimally-invasive gynecologic surgery and assess the impact of a patient educational intervention regarding proper opioid use/disposal.

Methods: Educational pamphlets were provided preoperatively. Patients underwent hysterectomy, myomectomy, or other laparoscopic procedures.

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Article Synopsis
  • Perioperative venous thromboembolism (VTE) is a serious issue for patients undergoing gynecologic cancer surgery, prompting a study focused on improving compliance with preventative measures.
  • The study utilized a pre/post design, targeting a rise in VTE chemoprophylaxis from 22% to 90% by standardizing protocols across four key areas: preoperative procedures, surgical time-outs, postoperative care, and staff education.
  • Results showed a significant increase in compliance to 82% overall in the quality improvement cohort, with zero cases of VTE in this group compared to 2% in the historical cohort, demonstrating the success of the intervention.
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Objective: To identify patient, clinical and hospital factors associated with long-term survival (≥10 years) in women with serous ovarian cancer.

Methods: This National Cancer Database cohort study included women with stage II-IV serous ovarian cancer. Multivariate logistic regression models were used to examine the association of long-term survival with patient (race, insurance, location, household income, education, distance traveled), clinical (age, comorbidities, stage, grade, primary treatment) and hospital factors (region, institution, hospital volume ≥20).

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Background And Objectives: This study aims to characterize the utilization of minimally invasive myomectomy in the United States and to identify the patient and hospital factors associated with surgical approach to myomectomy.

Methods: This is a cross-sectional study using the National Inpatient Sample database. We extracted women aged 18-50 years who underwent open and minimally invasive (laparoscopic and robotic) myomectomy (MIM) from January 1, 2010-December 31, 2014.

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Objective: To collect, summarize, and evaluate the currently available intraoperative rating tools used in abdominal minimally invasive gynecologic surgery (MIGS).

Data Sources: Medline, Embase, and Scopus databases from January 1, 2000, to May 12, 2020.

Methods Of Study Selection: A systematic search strategy was designed and executed.

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Objective: To evaluate the role of screening patients at increased risk for hereditary cancer syndromes with an extended panel of cancer predisposition genes to identify actionable genetic mutations.

Methods: A retrospective chart review was conducted of all patients presenting to a multidisciplinary cancer program for genetic counseling and testing from January 2015 to December 2016. Individuals presenting to the program were identified as at-risk by a personal or family history of cancer, by their health care provider, or by self-referral.

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•There is no consensus on optimal treatment for GTN and brain metastases.•Brain metastasis treated with craniotomy and intravenous, EMA-CO chemotherapy•Intravenous high-dose methotrexate may be adequate to treat brain metastases.

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