Age-dependent cellular reactions of the human immune system of humanized NOD scid gamma mice on LPS stimulus.

Despite sepsis being a life-threatening disease, targeted drugs that improve the therapy of affected patients are still lacking. Infants and adults differ in the maturity level of their immune system and this results in distinct reactions to Gram-negative bacteria. To study reactions of human immune cells in vivo, we used NOD scid gamma mice transplanted with human CD34 stem cells to engraft a functional human immune system.