Noninferiority of Artificial Intelligence-Assisted Analysis of Ki-67 and Estrogen/Progesterone Receptor in Breast Cancer Routine Diagnostics.

Image analysis assistance with artificial intelligence (AI) has become one of the great promises over recent years in pathology, with many scientific studies being published each year. Nonetheless, and perhaps surprisingly, only few image AI systems are already in routine clinical use. A major reason for this is the missing validation of the robustness of many AI systems: beyond a narrow context, the large variability in digital images due to differences in preanalytical laboratory procedures, staining procedures, and scanners can be challenging for the subsequent image analysis.

Fallbericht über eine an COVID-19 erkrankte Patientin mit bestehendem Schmerzsyndrom.

Patient with COVID-19 and pre-existing pain syndrome This paper focuses on the case study of a patient in the UK who showed - as far as we know today - all typical symptoms of an infection with SARS-CoV-2 but without dyspnoea. The diagnose was made on the basis of the symptoms, which were described by the patient, and confirmed by an antibody test in August 2020. Due to the public interest in knowing more about the cluster of symptoms and their implications for nursing, the patient and the author of this paper decided to present this case study to the professional audience.

Instant evaluation of contrast enhanced endoscopic ultrasound helps to differentiate various solid pancreatic lesions in daily routine.

Background: Contrast enhanced harmonic endoscopic ultrasound (CEH-EUS) is a spreading technique; some studies have shown its value in the diagnosis of pancreatic adenocarcinoma using quantitative analysis.

Aim: To examine the value of CEH-EUS for differentiating various pancreatic lesions in everyday routine with qualitative and quantitative analysis.

Methods: Data of 55 patients with pancreatic lesions who underwent CEH-EUS were analysed retrospectively.

Papillary Thyroid Cancer and Coexisting Autoimmune Thyroiditis.

Histological findings often display an association between papillary thyroid carcinomas (PTC) and autoimmune thyroiditis (AIT) and so differ significantly from follicular thyroid carcinomas (FTC). The aim of this interdisciplinary, retrospective study was to evaluate the association of AIT in patients with PTC and FTC and a control group of benign nodular goiters. One hundred thyroidectomies with histologically confirmed differentiated thyroid carcinomas, 67 with PTC and 33 with FTC, were submitted for examination.

In-situ tissue regeneration through SDF-1α driven cell recruitment and stiffness-mediated bone regeneration in a critical-sized segmental femoral defect.

Unlabelled: In-situ tissue regeneration aims to utilize the body's endogenous healing capacity through the recruitment of host stem or progenitor cells to an injury site. Stromal cell-derived factor-1α (SDF-1α) is widely discussed as a potent chemoattractant. Here we use a cell-free biomaterial-based approach to (i) deliver SDF-1α for the recruitment of endogenous bone marrow-derived stromal cells (BMSC) into a critical-sized segmental femoral defect in rats and to (ii) induce hydrogel stiffness-mediated osteogenic differentiation in-vivo.

Effect of exogenous fibrolytic enzymes on performance and blood profile in early and mid-lactation Holstein cows.

The supplementation of exogenous fibrolytic enzymes (EFE) to dairy cows diets could be a strategy to improve fiber degradation in the rumen which is especially important for the early lactating cows characterized by a high milk energy output and an insufficient energy intake. The objective of this study was to examine the effects of a fibrolytic enzyme product (Roxazyme G2 Liquid, 3.8 and 3.

Force-feeding is in the interests of the state, not its prisoners.

Further to Paul Hegarty's letter, 'Force-feeding is wrong and nurses should play no part' (July 30), the International Council of Nurses is clear about the role of nurses.

One night of partial sleep deprivation affects habituation of hypothalamus and skin conductance responses.

Sleep disturbances are prevalent in clinical anxiety, but it remains unclear whether they are cause and/or consequence of this condition. Fear conditioning constitutes a valid laboratory model for the acquisition of normal and pathological anxiety. To explore the relationship between disturbed sleep and anxiety in more detail, the present study evaluated the effect of partial sleep deprivation (SD) on fear conditioning in healthy individuals.

Contrast-enhanced harmonic endoscopic ultrasound is able to discriminate benign submucosal lesions from gastrointestinal stromal tumors.

Background: Although endoscopic ultrasound (EUS) has improved the diagnostic of potential malignancies, gastric lesions with suspicion of gastrointestinal stromal tumors (GIST) or benign lesions like lipoma or leiomyoma can often not be accurately differentiated by EUS, therefore, requiring tissue sampling with the risk of bleeding complications especially in GIST. As with the newest generation of EUS machines, contrast-enhanced harmonic endoscopic ultrasound (CEH-EUS) has become a new option to determine perfusion characteristics. The aim of this analysis was to evaluate whether CEH-EUS may help to discriminate various submucosal lesions.

[Sterilization surgeon and researcher: life and career of Benno Ottow (1884-1975)].

The activities of the gynaecologist and member of the Erbgesundheitsgericht Benno Ottow (1884-1975) in the "Third Reich" have been described in a couple of publications. During the Nazi dictatorship Ottow demonstrated great commitment to putting the ideological and legal demands into practice. Drawing on sources from private and state archives in Estonia, Germany and Sweden, this paper investigates the biography of Benno Ottow: from his time as a junior physician period in Estonia and Russia to his directorship of the Brandenburg gynaecological state hospital in Berlin-Neukölln and the postwar-years in Sweden.

A 5-mm femoral defect in female but not in male rats leads to a reproducible atrophic non-union.

Introduction: The objectives of this study were to (1) establish a reproducible atrophic non-union model in rats by creation of a segmental femoral bone defect that allows, (2) in-depth characterization of impaired healing, and (3) contrast its healing patterns to the normal course. Hypothesis was that a 5-mm bone defect in male rats would deviate from uneventful healing patterns and result in an atrophic non-union.

Materials And Methods: A femoral osteotomy was performed in two groups of 12-week-old male rats (1 vs.

Standard bone healing stages occur during delayed bone healing, albeit with a different temporal onset and spatial distribution of callus tissues.

Bone healing is considered as a recapitulation of a developmental program initiated at the time of injury. This study tested the hypothesis that in delayed bone healing the regular cascade of healing events, including remodeling of woven to lamellar bone, would be similar compared to standard healing, although the temporal onset would be delayed. A tibial osteotomy was performed in sheep and stabilized with a rotationally unstable fixator leading to delayed healing.

Effect of exogenous fibrolytic enzymes on ruminal fermentation and nutrient digestion in dairy cows.

The aim of the present study was to examine the effects of an exogenous fibrolytic enzyme product applied to a total mixed ration (TMR) prior to feeding on ruminal fermentation, microbial protein synthesis, nutrient digestion, and milk yield and composition. Six multiparous lactating Holstein cows (598 +/- 29 kg initial live weight and 98 +/- 30 days in milk) fitted with rumen and duodenal cannulae were allocated to two treatments in a crossover design over three consecutive 28-d periods. The TMR containing 50% concentrates, 30% corn silage and 20% grass silage on dry matter (DM) basis, was mixed once daily and fed twice a day.

Insight into the molecular pathophysiology of delayed bone healing in a sheep model.

Delayed and nonunions are still challenging problems. In this study, we examined the endogenous mRNA expression of genes regulating cartilage formation, bone formation, endochondral ossification, and bone remodeling during mechanically induced delayed bone healing in a large animal model. A tibial osteotomy was performed in two groups of sheep and stabilized with either a rigid external fixator leading to standard healing or with a rotationally unstable fixator leading to delayed healing.

Locally applied osteogenic predifferentiated progenitor cells are more effective than undifferentiated mesenchymal stem cells in the treatment of delayed bone healing.

Mesenchymal stem cells (MSCs) and osteogenic predifferentiated cells (OPCs) have been shown to promote healing of critical-sized bone defects. This study investigated the regenerative capacity of autologous MSCs versus OPCs after local injection into a compromised bone healing situation. We hypothesized that treatment with MSCs and OPCs would enhance the healing and that the MSCs would be more effective due to their lower differentiation and higher proliferative competence.

Differential regulation of blood vessel formation between standard and delayed bone healing.

Blood vessel formation is a prerequisite for bone healing. In this study, we tested the hypothesis that a delay in bone healing is associated with an altered regulation of blood vessel formation. A tibial osteotomy was performed in two groups of sheep and stabilized with either a rigid external fixator leading to standard healing or with a highly rotationally unstable one leading to delayed healing.

A quarter century of the analysis of verbal behavior: an analysis of impact.

The Analysis of Verbal Behavior (TAVB) has been published since 1982, and during this time, interest in verbal behavior research appears to have increased substantially within behavior analysis. The purpose of the present analysis was to assess the influence of TAVB on the field by (a) counting citations of TAVB articles in the Journal of the Experimental Analysis of Behavior (JEAB) and the Journal of Applied Behavior Analysis (JABA) from 1983 through 2007, (b) examining which other journals cite TAVB, and (c) calculating impact-factor estimates for 2003 through 2007. Citations of TAVB articles began to appear in JEAB and JABA in the late 1980s to early 1990s, and by the end of 2007, almost a third of all articles published in TAVB had been cited in either JEAB or JABA.

'Arzteführerschule Alt-Rehse'--the main educational centre for promotion of Nazi medicine ideology in Germany during 1935 - 1943.

In Nazi Germany 1933-1945 the medical profession played an important role, not only within the health sector but also for ideological purposes. Some physicians committed criminal acts during the war, for example in concentration camps, and where later put on trial at the Nuremberg Trials in 1946-1947, some of them also sentenced to death. What is little known outside Germany is the existence of a specialised political leader school for physicians, dentists, midwives, pharmacists, and health officials at Alt-Rehse, a small village north of Berlin in the province of Mecklenburg, Northern Germany.

Binding of recombinant mistletoe lectin (aviscumine) to resected human adenocarcinoma of the lung.

Background: Lectins, carbohydrate proteins, bind to glycoconjugates of all mammalian cells, including cancer cells. Aberrant glycosylation, detected by lectin histochemistry, can predict outcome in some tumour entities. One such lectin is aviscumine (recombinant mistletoe lectin).

Expression of CEACAM1 in adenocarcinoma of the lung: a factor of independent prognostic significance.

Purpose: To evaluate the prognostic relevance of CEACAM1 and sialyl Lewis X expression in adenocarcinomas of the lung.

Patients And Methods: Paraffin wax sections of 93 patients with adenocarcinomas of the lung who underwent surgery between 1990 and 1995 were immunohistochemically investigated using monoclonal anti-CEACAM1 and sialyl Lewis X antibodies. The clinical course of all patients was followed up for a minimum of 5 years.

Lectin histochemistry of resected adenocarcinoma of the lung: helix pomatia agglutinin binding is an independent prognostic factor.

The worldwide incidence of adenocarcinoma of the lung is rising. Unfortunately, no significant prognostic marker beyond the classical TNM staging exists to stratify these patients for appropriate therapy. Because lectins, carbohydrate-binding proteins, have been shown to be useful prognostic markers in several other adenocarcinomas, a panel of lectins [Helix pomatia agglutinin (HPA), Phaseolus vulgaris leukoagglutinin, Ulex europaeus agglutinin, Maackia amurenis agglutinin, Sambucus nigra agglutinin] with different carbohydrate-binding specificities were tested for their prognostic relevance.