Solid-state structure and antimicrobial and cytotoxicity studies of a cucurbit[6]uril-like CuL constructed from 3,5-bis[(1H-tetrazol-5-yl)methyl]-4H-1,2,4-triazol-4-amine.

3,5-Bis[(1H-tetrazol-5-yl)methyl]-4H-1,2,4-triazol-4-amine (HL) associates under deprotonation with CuSO in aqueous medium to form a new waisted barrel-shaped ML cluster, namely hexaaquatetrakis{μ-3,5-bis[(1H-tetrazol-5-yl)methyl]-4H-1,2,4-triazol-4-amine}-μ-sulfato-hexacopper(II) sulfate hydrate, [Cu(SO)(CHN)(HO)]SO·nHO (n = ∼23) (1). Cluster 1 resembles concave cucurbit[6]uril and has one disordered sulfate anion trapped inside the cage, which additionally stabilizes the Cu unit. The Cu ions have either a square-pyramidal or a distorted octahedral geometry.

Synthesis of New Polyether Ether Ketone Derivatives with Silver Binding Site and Coordination Compounds of Their Monomers with Different Silver Salts.

Polyether ether ketone () is a well-known polymer used for implants and devices, especially spinal ones. To overcome the biomaterial related infection risks, 4-4'-difluorobenzophenone, the famous monomer, was modified in order to introduce binding sites for silver ions, which are well known for their antimicrobial activity. The complexation of these new monomers with different silver salts was studied.

Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis.

Tumour microenvironment greatly influences the development and metastasis of cancer progression. The development of three dimensional (3D) culture models which mimic that displayed in vivo can improve cancer biology studies and accelerate novel anticancer drug screening. Inspired by a systems biology approach, we have formed 3D in vitro bioengineered tumour angiogenesis microenvironments within a glycosaminoglycan-based hydrogel culture system.