Publications by authors named "Anja Arner"

Article Synopsis
  • Acute lymphoblastic leukemia (ALL) is the most prevalent cancer in children, and while initial treatment outcomes are typically positive, relapses lead to poor prognoses.
  • The study introduced a zebrafish xenotransplantation model for better understanding the complex interactions between leukemic cells and their tumor microenvironment, enhancing the ability to analyze cell behavior in real-time.
  • Findings revealed that leukemic cells proliferated in a specific hematopoietic niche and displayed distinct patterns of movement, forming clusters, which could help researchers investigate how niche interactions contribute to leukemia progression and relapse.
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High-throughput sequencing describes multiple alterations in individual tumors, but their functional relevance is often unclear. Clinic-close, individualized molecular model systems are required for functional validation and to identify therapeutic targets of high significance for each patient. Here, we establish a Cre-ER-loxP (causes recombination, estrogen receptor mutant T2, locus of X-over P1) based inducible RNAi- (ribonucleic acid interference) mediated gene silencing system in patient-derived xenograft (PDX) models of acute leukemias in vivo.

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Severe side effects often restrict clinical application of the widely used chemotherapeutic drug doxorubicin. In order to decrease required substance concentrations, new concepts for successful combination therapy are needed. Since doxorubicin causes DNA damage, combination with compounds that modulate DNA repair could be a promising strategy.

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