Publications by authors named "Anita Rebecca Pedrinelli"
More than three years have passed since the first case, and COVID-19 is still a health concern, with several open issues such as the lack of reliable predictors of a patient's outcome. Osteopontin (OPN) is involved in inflammatory response to infection and in thrombosis driven by chronic inflammation, thus being a potential biomarker for COVID-19. The aim of the study was to evaluate OPN for predicting negative (death or need of ICU admission) or positive (discharge and/or clinical resolution within the first 14 days of hospitalization) outcome.
View Article and Find Full Text PDFA total of 63 myeloproliferative neoplasms [MPN; 9 polycythemia vera (PV), 32 essential thrombocythemia (ET), and 22 myelofibrosis (MF)] underwent spleen stiffness (SS) measurement by vibration-controlled transient elastography equipped with a novel spleen-dedicated module. Higher SS values significantly correlated with grade 2-3 bone marrow (BM) fibrosis (=0.035), with hemoglobin level <10 g/dl (=0.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on understanding the varied prognosis of COVID-19 by identifying clinical and laboratory indicators that can predict poor outcomes in hospitalized patients.
- Researchers analyzed data from 664 COVID-19 patients in Northern Italy, discovering that factors like red cell distribution width (RDW), neutrophil-to-lymphocyte (NL) ratio, and platelet count are significant predictors of in-hospital mortality.
- The results suggest that using simple blood tests could help in classifying the severity of COVID-19, ultimately guiding treatment and monitoring strategies for better patient management.
Article Synopsis
- The study examined COVID-19 case fatality rates (CFR) and mortality predictors in Northern Italy during March-April 2020.
- Out of 1,697 hospitalized patients, 504 died, resulting in an overall CFR of 29.7%.
- Key predictors of mortality identified were age, cancer diagnosis, obesity, and smoking, with laboratory data reinforcing the significance of age, cancer diagnosis, and baseline PaO/FiO ratio.