Generation and analysis of clinically relevant breast imaging x-ray spectra.

Purpose: The purpose of this work was to develop and make available x-ray spectra for some of the most widely used digital mammography (DM), breast tomosynthesis (BT), and breast CT (bCT) systems in North America.

Methods: The Monte Carlo code MCNP6 was used to simulate minimally filtered (only beryllium) x-ray spectra at 8 tube potentials from 20 to 49 kV for DM/BT, and 9 tube potentials from 35 to 70 kV for bCT. Vendor-specific anode compositions, effective anode angles, focal spot sizes, source-to-detector distances, and beryllium filtration were simulated.

Differentiation of ductal carcinoma in-situ from benign micro-calcifications by dedicated breast computed tomography.

Purpose: Compare conspicuity of ductal carcinoma in-situ (DCIS) to benign calcifications on unenhanced (bCT), contrast-enhanced dedicated breast CT (CEbCT) and mammography (DM).

Methods And Materials: The institutional review board approved this HIPAA-compliant study. 42 women with Breast Imaging Reporting and Data System 4 or 5 category micro-calcifications had breast CT before biopsy.

Mean glandular dose coefficients (D(g)N) for x-ray spectra used in contemporary breast imaging systems.

To develop tables of normalized glandular dose coefficients D(g)N for a range of anode-filter combinations and tube voltages used in contemporary breast imaging systems. Previously published mono-energetic D(g)N values were used with various spectra to mathematically compute D(g)N coefficients. The tungsten anode spectra from TASMICS were used; molybdenum and rhodium anode-spectra were generated using MCNPX Monte Carlo code.

Radiation dosimetry in digital breast tomosynthesis: report of AAPM Tomosynthesis Subcommittee Task Group 223.

The radiation dose involved in any medical imaging modality that uses ionizing radiation needs to be well understood by the medical physics and clinical community. This is especially true of screening modalities. Digital breast tomosynthesis (DBT) has recently been introduced into the clinic and is being used for screening for breast cancer in the general population.

Comprehensive assessment of the slice sensitivity profiles in breast tomosynthesis and breast CT.

Purpose: This study experimentally evaluated the slice sensitivity profile (SSP) and its relationship between acquisition angle, object size, and cone angle. The sensitivity profile metric was used to characterize a breast tomosynthesis system's resolution in the z-axis. The SSP was also measured on a prototype breast computed tomography (bCT) system.

Anatomical complexity in breast parenchyma and its implications for optimal breast imaging strategies.

Purpose: The purpose of this investigation was to assess the anatomical noise in breast images using a mathematically derived parameter β as a surrogate for detection performance, across the same patient cohort but in different imaging modalities including mammography, tomosynthesis, and breast CT.

Methods: Women who were scheduled for breast biopsy were approached for participation in this IRB and HIPPA-compliant investigation. A total of 23 women had all views of each modality and represent the cohort studied in this investigation.

Experimental validation of a method characterizing bow tie filters in CT scanners using a real-time dose probe.

Purpose: Beam-shaping or "bow tie" (BT) filters are used to spatially modulate the x-ray beam in a CT scanner, but the conventional method of step-and-shoot measurement to characterize a beam's profile is tedious and time-consuming. The theory for characterization of bow tie relative attenuation (COBRA) method, which relies on a real-time dosimeter to address the issues of conventional measurement techniques, was previously demonstrated using computer simulations. In this study the feasibility of the COBRA theory is further validated experimentally through the employment of a prototype real-time radiation meter and a known BT filter.