Systemic effect of arecoline on the gastrointestinal system in oral submucous fibrosis affected wistar rats.

Background: The intestine plays an important role in the digestion and absorption of ingested food and the elimination of undigested food, microbes, and microbial products. The functional reliability of the intestinal mucosal epithelial cells depends on the organised regulation of the epithelial cells, mucus layer, the intercellular tight junction, host innate and acquired immune response. The mucus layer of the gastrointestinal tract is the first line of innate host defense, essentially because of the secretory products of intestinal cells.

Computational simulations of identified marine-derived natural bioactive compounds as potential inhibitors of oral cancer.

Oral squamous cell carcinoma is characterized by the upregulation of RAC-alpha serine/threonine-protein kinase (Akt1) and RAC-beta serine/threonine-protein kinase (Akt2). In this work, Akt1 and Akt2 were inhibited using a cocktail of 20 marine algae chemicals. From the PyRx Virtual Screening Tool, dieckol, 6,6'-bieckol, siphonaxanthin and sargachromanol E were chosen as the best four compounds for Akt1 based on the scoring.

Thiolated polymer nanocarrier reinforced with glycyrrhetinic acid for targeted delivery of 5-fluorouracil in hepatocellular carcinoma.

The present work investigates the targeting efficacy of a novel thiolated polymer-based nanocomposite reinforced with glycyrrhetinic acid (GA) and loaded with 5-fluorouracil in hepatocellular carcinoma (HCC). The thiolated polymers were synthesized by EDAC-mediated conjugation reactions and lyophilization. The nanoparticles were prepared by solvent diffusion and high-pressure homogenization method.

Toxicological evaluation of greville derived fucoidan in wistar rats: Haematological, biochemical and histopathological evidences.

Objective: The present study aimed to investigate the acute and subacute toxicity profile of fucoidan obtained from Greville, a brown marine algae in order to assess its safety.

Methods: Fucoidan was isolated from Greviile and subjected to FTIR analysis to confirm the functional groups. In acute toxicity study, a single dose of fucoidan (2000 mg/kg) was orally administered to three female rats as per OECD guideline 423.

Phytochemical Screening and Toxicological Evaluation of Greville in Wistar Rats.

Objectives: The present study was conducted to identify the phytoconstituents present in different extracts of and to assess the toxicity of its ethanol extract.

Materials And Methods: Successive solvent extraction and total ethanol extraction of were performed and preliminary phytochemical screening was carried out. The acute toxicity of ethanol extract of (ESW) was studied.

Studies on anti-hyperglycemic effect of Euphorbia antiquorum L. root in diabetic rats.

Background/aim: To determine the anti-hyperglycemic effect of Euphorbia antiquorum L. root.

Materials And Methods: The study evaluates the anti-hyperglycemic effect of E.

In vitro antioxidant and anticancer activity studies on drosera indica L. (Droseraceae).

Purpose: The aim of present in vitro studies was performed to examine the antioxidant and anticancer activities of ethanol and aqueous extracts of Drosera indica L.

Methods: Different concentrations (5 - 640mcg/ml) of the ethanol (EEDI) and aqueous (AEDI) extracts of D.indica L were used in various antioxidant assay methods such as hydroxyl radicals, DPPH, super oxide radical scavenging activity, chelating ability of ferrous ion, nitric oxide radical inhibition, ABTS and reducing power.

Effect of Smilax zeylanica roots and rhizomes in paracetamol induced hepatotoxicity.

Context: Smilax zeylanica L.(Smilacaceae) is a climbing shrub with woody prickly stems.

Objective: This study evaluated the hepatoprotective effect of S.

Protective effects of Capparis sepiaria root extracts against acetaminophen-induced hepatotoxicity in Wistar rats.

Capparis sepiaria L. known as Himsra is an important drug in Ayurveda. In this study extracts of the root of C.