Data on the optimisation of GC-MS/MS method for the simultaneous determination of compounds from food contact material.

Food contact materials (FCM) made of plastic materials contain various additives, e.g. plasticisers, UV-stabilisers, preservatives, antioxidants, etc.

Development of a SPME-GC-MS/MS method for the determination of some contaminants from food contact material in beverages.

The development and validation of a simple, low-cost, and sensitive method for the determination of nine compounds expected in beverages and vinegar as a result of migration from food contact material (parabens, phenolic antioxidants, sulfonamide plasticizer, and flame retardant) is presented. The analytes were preconcentrated using solid-phase microextraction and analyzed by gas chromatography - tandem mass spectrometry. The method required no derivatization procedure and an affordable chemical was used as internal standard.

Identification of new impurities of enalapril maleate on oxidation in the presence of magnesium monoperoxyphthalate.

Stress stability testing and forced degradation were used to determine the stability of enalapril maleate (EM) and to find a degradation pathway for the drug. The degradation impurities, formed under different stressed conditions, were investigated by HPLC and UPLC-MS methods. HPLC analysis showed several degradation impurities of which several were already determined, but on oxidation in the presence of magnesium monoperoxyphthalate (MMPP) several impurities of EM were observed which were not yet characterized.

Determination of serum lysophosphatidic acid as a potential biomarker for ovarian cancer.

A fast and selective analytical method, used to determine the different lysophosphatidic acid (LPA) species in serum, has been developed and validated. LPA species were quantitatively extracted from serum using methanol-chloroform (2:1, v/v). The proteins were precipitated by this solvent mixture and separated by centrifugation in one step.

Determination of glutathione in spruce needles by liquid chromatography/tandem mass spectrometry.

For the determination of glutathione (GSH) and its oxidized form (GSSG) in spruce needles their electrospray mass and MS/MS spectra were recorded with an ion trap mass spectrometer (ITMS, LCQ, Finnigan) and a triple stage quadrupole mass spectrometer (TSQ, Quattro II, Micromass). A study of the stability of GSH in aqueous solutions shows the presence of dimeric and trimeric forms of GSH, as well as GSSG, GSH-sulfonate and GSH-sulfinic acid. The same components were also found in extracts of spruce needles.