Pullulan based oral thin film formulation of zolmitriptan: Development and optimization using factorial design.

The goal of study was to formulate and characterize pullulan based oral thin film (OTF) of zolmitriptan by solvent casting method. Based on preliminary trials, glass, PEG 400 and sucralose were selected as casting surface, water-miscible plasticizer and sweetener for OTF, respectively. A 3 factorial design was used to study the effect of amount of PEG 400 (X) and sucralose (X) as independent variables on tensile strength (Y), elasticity (Y), % in-vitro drug release in phosphate buffer of pH 6.

Development and optimization of modified release IPN macromolecules of oxcarbazepine using natural polymers.

The study shows development and optimization of modified release interpenetrating polymer network (IPN) macromolecules (beads) of oxcarbazepine using sodium alginate-egg albumin prepared by ionotropic gelation method and CaCl2 as a cross-linker. Independent variables were identified based on preliminary study of investigation. The effect of amount of both polymers on drug entrapment efficiency (DEE,%), bead size (μm) and cumulative drug release at 8 h (Q8h, %) were optimized using 3(2) factorial design.