Publications by authors named "Anita Krnjic"
Inflammatory bowel disease is a group of conditions with rising incidence caused by genetic and environmental factors including diet. The chelator ethylenediaminetetraacetate (EDTA) is widely used by the food and pharmaceutical industry among numerous other applications, leading to a considerable environmental exposure. Numerous safety studies in healthy animals have revealed no relevant toxicity by EDTA.
View Article and Find Full Text PDFA Novel PAK1-Notch1 Axis Regulates Crypt Homeostasis in Intestinal Inflammation.
Cell Mol Gastroenterol Hepatol
December 2021
Background & Aims: p21-activated kinase-1 (PAK1) belongs to a family of serine-threonine kinases and contributes to cellular pathways such as nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT), and Wingless-related integration site(Wnt)/β-catenin, all of which are involved in intestinal homeostasis. Overexpression of PAK1 is linked to inflammatory bowel disease as well as colitis-associated cancer (CAC), and similarly was observed in interleukin (IL)10 knockout (KO) mice, a model of colitis and CAC. Here, we tested the effects of PAK1 deletion on intestinal inflammation and carcinogenesis in IL10 KO mice.
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- Iron deficiency (ID) is widespread and linked not only to anemia but also to an increased risk of thrombosis, which could lead to further complications.
- In a study using animal models, ID was shown to cause higher platelet counts and larger thrombus sizes, demonstrating a clear connection between ID and increased thrombotic tendency.
- Iron replacement therapy effectively corrected the changes caused by ID, suggesting it could be a useful preventive measure for thrombotic diseases in patients with chronic illnesses predisposed to thrombosis.
Article Synopsis
- The study investigates how 5-ASA and AZTP, two treatments for inflammatory bowel disease (IBD), help restore the mucosal barrier that is often disrupted in IBD.
- Both drugs improve epithelial barrier function by affecting cellular structures and proteins, particularly tight junctions, which are crucial for maintaining the intestinal lining.
- While 5-ASA supports wound healing and alters cell cycle distribution in epithelial cells, AZTP has antiproliferative effects; both contribute to resolving barrier dysfunction but through different biological mechanisms.
The mucosal immune response in the setting of intestinal inflammation contributes to colorectal cancer. IL10 signaling has a central role in gut homeostasis and is impaired in inflammatory bowel disease (IBD). Out of two IL10 receptor subunits, IL10R1 and IL10R2, the latter is shared among the IL10 family of cytokines and activates STAT signaling.
View Article and Find Full Text PDFBackground: Chronic gut inflammation predisposes to the development of colorectal cancer and increased mortality. Use of mesalamine (5-ASA) in the treatment of ulcerative colitis modulates the risk of neoplastic progression. p21 activated kinase 1 (PAK1) mediates 5-ASA activity by orchestrating MAPK signaling, Wnt-β catenin pathway, and cell adhesion; all implicated in the colon carcinogenesis.
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