A Novel Treatment Approach to Treatment-Resistant, Recurrent .

A 36-year-old male with a previous medical history of persistent presented to clinic for evaluation of diarrheal symptoms intermittently for the last 2 years. He reported recurrent episodes of that initially began after prophylactic antibiotic use prior to a tooth extraction. He underwent 12 unsuccessful treatment trials at a nearby clinic with courses of vancomycin, metronidazole, and fidaxomicin.

Published Support for Wellness, Diversity, Equity, and Inclusion Among Internal Medicine Residency Program Websites.

Introduction: The objective of this study was to review internal medicine residency program websites in the United States based on their published support for wellness, diversity, equity, and inclusion concepts. Inclusion of wellness, diversity, equity, and inclusion on program websites can serve as critical student benchmarks, and it may be paramount to optimize residency program websites accordingly.

Methods: This is a cross-sectional study of the websites of 597 internal medicine residency programs accredited by the Accreditation Council for Graduate Medical Education between March 25 and April 25, 2022.

Postinfectious Inflammatory Syndrome following Cryptosporidium Infection.

A 38-year-old woman with a history of Crohn's disease, multiple bowel resections, and ileostomy placement presented to the hospital with symptoms of increased ileostomy output for 1 week. She reported that she was emptying her bag fifteen times a day as opposed to her normal 3-4 times a day. Upon workup, she was found to have an acute kidney injury (AKI), and stool studies were positive for .

Transcriptional and Non-Transcriptional Activation, Posttranslational Modifications, and Antiviral Functions of Interferon Regulatory Factor 3 and Viral Antagonism by the SARS-Coronavirus.

The immune system defends against invading pathogens through the rapid activation of innate immune signaling pathways. Interferon regulatory factor 3 (IRF3) is a key transcription factor activated in response to virus infection and is largely responsible for establishing an antiviral state in the infected host. Studies in mice have demonstrated the absence of IRF3 imparts a high degree of susceptibility to a wide range of viral infections.