Male-only fresh-frozen plasma for transfusion-related acute lung injury prevention: before-and-after comparative cohort study.

Background: Transfusion-related acute lung injury (TRALI) is one of the most serious complications of blood transfusion. It can be caused by incompatible white blood cell antibodies in transfused plasma. The objective of this study was to quantify the reduction of TRALI after introduction of male-only plasma for transfusion as a preventive measure, which took effect in 2007.