Publications by authors named "Anita Dongre"
Problem: Recurrent pregnancy loss (RPL) is the spontaneous loss of two or more consecutive pregnancies prior to 20 weeks of gestation, occurring in 1% of the reproductive-age population. It is a major cause of infertility in India with a staggering 7.46% prevalence rate.
View Article and Find Full Text PDFBackground: As per WHO, Cervical cancer (CaCx) is a global issue, being the fourth common cancer in women with incidence rate of 13.1 per 1 lakh women globally and accounting for 311000 deaths in the year 2018 itself globally. The molecular pathogenesis in Human papillomavirus (HPV) infected cases is inconclusive.
View Article and Find Full Text PDFArticle Synopsis
- - This study investigates the role of telomerase and cervical cancer stem cells (CSCs) in the development of cervical cancer (CaCx) in patients infected with HPV16, focusing on 65 cases from Northeast India.
- - Researchers analyzed the expression of viral proteins E6 and E7, as well as telomerase components (hTERT and hTR) using techniques like real-time PCR and immunofluorescence, finding that these factors correlate with CaCx severity and susceptibility.
- - The results suggest that the interaction between the telomerase pathway and CSC marker OCT4, particularly influenced by HPV16 E6 protein expression, could be important for both understanding cervical cancer pathogenesis and developing potential therapies. *
Article Synopsis
- The study examines the link between human papillomavirus (HPV) infection and cervical cancer (CaCx) in an ethnically unique population from Northeast India, focusing on the immune response.
- It involves analyzing 76 CaCx cases, 25 cases of cervical intraepithelial neoplasia (CIN), and 50 healthy controls, using techniques like PCR for HPV screening and various assays to measure cytokine levels.
- Results show that TNF-α is downregulated in CaCx, and its decreasing levels correlate with disease progression, while the HPV16 E6 and E7 viral transcripts are significantly upregulated, indicating a critical interaction between immune response and HPV-mediated cervical cancer development.