Publications by authors named "Anita Dharan"
Article Synopsis
- Researchers investigated the experiences of individuals in Australia with Debilitating Symptom Complexes Attributed to Ticks (DSCATT) to help create better treatment options.
- *The study involved interviews with 13 participants who, despite linking their symptoms to tick bites, were not all convinced they had Lyme disease; many reported negative experiences with healthcare that worsened their conditions.
- *The findings highlight a significant need for compassionate and patient-centered care, as well as effective treatments that address both the physical and mental health challenges associated with DSCATT.*
Article Synopsis
- The study investigates N-acetylcysteine (NAC) as a potential treatment for adults with treatment-resistant PTSD, focusing on its effects on oxidative stress in the brain.
- Conducted as a randomized, double-blind, placebo-controlled trial, participants received either 2.7 g/day of NAC or a placebo for 12 weeks, with outcomes measured at baseline and follow-up points.
- Results showed no significant difference in PTSD symptoms between NAC and placebo at week 12, but improvements in craving duration and resistance were noted at week 64 for those taking NAC.
Objectives: Despite the prevalence of cognitive symptoms in the idiopathic generalized epilepsies (IGEs), cognitive dysfunction in juvenile absence epilepsy (JAE), a common yet understudied IGE subtype, remains poorly understood. This descriptive study provides a novel, comprehensive characterization of cognitive functioning in a JAE sample and examines the relationship between cognition and 24-h epileptiform discharge load.
Method: Forty-four individuals diagnosed with JAE underwent cognitive assessment using Woodcock Johnson III Test of Cognitive Abilities with concurrent 24-h ambulatory EEG monitoring.
This article describes source data from a systematic review and meta-analysis of electroencephalography (EEG) and magnetoencephalography (MEG) studies investigating functional connectivity in idiopathic generalized epilepsy. Data selection, analysis and reporting was performed according to PRISMA guidelines. Eligible studies for review were identified from human case-control, and cohort studies.
View Article and Find Full Text PDFFor idiopathic generalized epilepsies (IGE), brain network analysis is emerging as a biomarker for potential use in clinical care. To determine whether people with IGE show alterations in resting-state brain connectivity compared to healthy controls, and to quantify these differences, we conducted a systematic review and meta-analysis of EEG and magnetoencephalography (MEG) functional connectivity and network studies. The review was conducted according to PRISMA guidelines.
View Article and Find Full Text PDFBackground: Most patients with Posttraumatic Stress Disorder (PTSD) suffer residual symptoms following first-line treatment. Oxidative stress has been implicated in the pathophysiology of PTSD. N-acetylcysteine (NAC) is a precursor of the brain's primary antioxidant, glutathione, and may diminish oxidative cellular damage.
View Article and Find Full Text PDFObjective: The objective of this study was to evaluate the efficacy and tolerability of perampanel (PER) in late adjunctive treatment of focal epilepsy. We assessed outcomes 1) according to patients' clinical profiles and the broad mechanism of action (MoA) of concomitant antiepileptic drugs (AEDs) and 2) the effects of PER on adverse events, irritability, mood, and quality of life (QOL).
Methods: Consecutive patients commenced on PER at two epilepsy centers in Melbourne, Australia were identified.