Publications by authors named "Anita Delor"
Background: Patient registries are an important tool for networking medical caregivers and research, especially in the field of rare diseases. Individuals afflicted by multi-organ autoimmune diseases typically suffer from inflammation of multiple organs.
Project: GAIN (German genetic multi-organ Auto-Immunity Network) is the German network for research and therapy optimisation for individuals with congenital multi-organ autoimmune diseases.
Article Synopsis
- The NLRP3 inflammasome's activity, crucial for inflammation, is influenced by accessory proteins and different modifications, but the relationships among these factors are not fully understood.
- Research reveals that Bruton's tyrosine kinase (BTK), a key drug target, directly interacts with and phosphorylates NLRP3, impacting its regulation in immune cells.
- BTK enhances various aspects of NLRP3 activation, including its relocalization and assembly, suggesting that targeting BTK could be a new therapeutic strategy to control inflammation by regulating NLRP3 functions.