Publications by authors named "Anita Burgos"
The Immunoglobulin Superfamily Member Basigin Is Required for Complex Dendrite Formation in .
Front Cell Neurosci
November 2021
Coordination of dendrite growth with changes in the surrounding substrate occurs widely in the nervous system and is vital for establishing and maintaining neural circuits. However, the molecular basis of this important developmental process remains poorly understood. To identify potential mediators of neuron-substrate interactions important for dendrite morphogenesis, we undertook an expression pattern-based screen in larvae, which revealed many proteins with expression in dendritic arborization (da) sensory neurons and in neurons and their epidermal substrate.
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- Chemotherapy-induced peripheral neuropathy (CIPN) is a common and poorly understood side effect of cancer treatment that affects pain-sensing nerve cells, leading to degeneration and altered functioning.
- In a study using adult mouse sensory neurons, researchers found that the chemotherapy drug paclitaxel caused damage to these neurons and reduced their ability to respond to heat, but overexpression of integrins helped protect against this damage.
- The study highlights that paclitaxel disrupts the recycling of integrins, which are vital for neuron maintenance, and suggests that restoring integrin function may offer a potential therapeutic approach for mitigating CIPN effects.
Article Synopsis
- - The text discusses how rapid escape behaviors in response to harmful stimuli are crucial for survival, highlighting a lack of understanding regarding the mechanisms linking stimuli to coordinated responses.
- - Researchers identified specific interneurons called Down-and-Back (DnB) neurons in larvae that are activated by harmful heat and are critical for effective escape behaviors, such as body bending and rolling.
- - DnB neurons connect with nociceptive and mechanosensory neurons and interact with pre-motor circuits, coordinating the escape responses by promoting activity in Goro neurons, which are necessary for rolling movements.