Publications by authors named "Anita A Turk"
Article Synopsis
- - Large Language Models (LLMs), like ChatGPT and Microsoft Copilot, were tested to see how accurately they provided guideline-based care for colon cancer in simulated clinical scenarios.
- - Out of 108 responses, both LLMs correctly answered only 36% of the questions, with many responses missing vital information or containing inaccuracies.
- - Clinician responses were much more concise compared to LLMs, which produced lengthy and sometimes unclear guidance, indicating a need for significant improvements before these tools can be used in clinical decision support.
Colorectal cancer (CRC) is a complex disease with diverse etiologies and clinical outcomes. Despite considerable progress in development of CRC therapeutics, challenges remain regarding the diagnosis and management of advanced stage metastatic CRC (mCRC). In particular, the five-year survival rate is very low since mCRC is currently rarely curable.
View Article and Find Full Text PDFPatients with advanced gastrointestinal cancer often experience high symptom burden, which is associated with heightened distress in both patients and their family caregivers. Few interventions have been tested to jointly address patient and caregiver symptoms in advanced gastrointestinal cancer. In a randomized pilot trial, telephone-based, dyadic acceptance and commitment therapy (ACT) was found to be feasible in this population.
View Article and Find Full Text PDFBackground: Fatigue often interferes with functioning in patients with advanced cancer, resulting in increased family caregiver burden. Acceptance and commitment therapy, a promising intervention for cancer-related suffering, has rarely been applied to dyads coping with advanced cancer.
Aim: To examine the feasibility, acceptability, and preliminary efficacy of acceptance and commitment therapy for patient-caregiver dyads coping with advanced gastrointestinal cancer.
Article Synopsis
- Tumor boards at National Cancer Institute-designated Comprehensive Cancer Centers (NCI-CCCs) share expert insights, but these discussions typically don’t reach the broader oncology community.* -
- An oncologist-only Q&A website, theMednet, was utilized to document and distribute findings from these tumor board discussions, resulting in 368 Q&As that reached thousands of oncologists nationwide.* -
- The impact of the Q&As was significant, with many clinicians reporting confirmation of their practices or a willingness to change their future approaches based on the shared knowledge, ultimately enhancing patient care.*
Background: Inhibitors of poly(ADP-ribose) polymerase (PARP) proteins potentiate antitumor activity of platinum chemotherapy. This study sought to determine the safety and tolerability of PARP inhibitor talazoparib with carboplatin and paclitaxel.
Methods: We conducted a phase I study of talazoparib with carboplatin AUC5-6 and paclitaxel 80 mg/m days 1, 8, 15 of 21-day cycles in patients with advanced solid tumors.
Background: Fatigue interference with activities, mood, and cognition is one of the most prevalent and bothersome concerns of advanced gastrointestinal (GI) cancer patients. As fatigue interferes with patient functioning, family caregivers often report feeling burdened by increasing responsibilities. Evidence-based interventions jointly addressing cancer patient fatigue interference and caregiver burden are lacking.
View Article and Find Full Text PDFIndividuals with breast and ovarian cancer susceptibility gene 1 (BRCA1) or BRCA2 germline mutations have a significantly increased lifetime risk for breast and ovarian cancers. BRCA-mutant cancer cells have abnormal homologous recombination (HR) repair of DNA. In these tumors, the base excision repair (BER) pathway is important for cell survival.
View Article and Find Full Text PDFAn improved understanding of colorectal cancer as a collection of multiple cancer subtypes is paving the way to precision medicine-based treatments.
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