Publications by authors named "Anissa Jayathilake"
Article Synopsis
- - Glucose stimulation leads to changes in microtubule structures in pancreatic β-cells, which enhances insulin secretion, but knocking down CAMSAP2 reduces insulin levels and affects glucose-stimulated insulin secretion (GSIS) without altering insulin vesicle release.
- - Instead of stabilizing microtubules at their minus ends like in other cell types, CAMSAP2 primarily localizes to the Golgi apparatus in primary β-cells, which is unique to these cells and does not depend on its ability to bind to microtubules.
- - The presence of a distinct CAMSAP2 isoform in primary β-cells suggests it has a different role promoting trafficking between the Golgi and endoplasmic reticulum (
Cancer cell migration is highly heterogeneous, and the migratory capability of cancer cells is thought to be an indicator of metastatic potential. It is becoming clear that a cancer cell does not have to be inherently migratory to metastasize, with weakly migratory cancer cells often found to be highly metastatic. However, the mechanism through which weakly migratory cells escape from the primary tumor remains unclear.
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