Attempts to improve locoregional chemotherapy for the prevention of colonic cancer liver metastasis in the rat.

Aim Of The Study: To improve prophylactic local treatment of hepatic metastasis from colonic cancer cells in the rat.

Methods: The in vitro anticancer activity of 30 mn exposure to different drugs was first evaluated by dimethyl-thiazol-diphenyl-tetrazolium-bromide assay on confluent DHD/K12/PROb rat and HT29 human colonic cancer cells. Hepatic metastasis was induced by portal vein infusion of 12 x 106 PROb colonic cancer cells in syngenic BDIX rats.