Biocompatibility of Piezoelectric KNaNbO Thin Films on Platinized Silicon Substrates.

Lead-free piezoelectric ceramics like KNaNbO (KNN) represent an emerging class of biomaterials for medical technology, as they can be used as components in implantable microelectromechanical systems (MEMS) and bioactive scaffolds for tissue stimulation. Such functional materials can act as working components in future devices, and their addition to current implant designs can greatly improve the biological interaction between host and implant. Despite this, only a few reports have studied the biocompatibility of these materials with living cells.

Altered Brain Leptin and Leptin Receptor Expression in the 5XFAD Mouse Model of Alzheimer's Disease.

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by the accumulation of amyloid plaques and neurofibrillary tangles. Interestingly, individuals with metabolic syndromes share some pathologies with those diagnosed with AD including neuroinflammation, insulin resistance and cognitive deficits. Leptin, an adipocyte-derived hormone, regulates metabolism, energy expenditure and satiety via its receptor, LepR.

Altered Brain Adiponectin Receptor Expression in the 5XFAD Mouse Model of Alzheimer's Disease.

Metabolic syndromes share common pathologies with Alzheimer's disease (AD). Adiponectin, an adipocyte-derived protein, regulates energy metabolism via its receptors, AdipoR1 and AdipoR2. To investigate the distribution of adiponectin receptors (AdipoRs) in Alzheimer's, we examined their expression in the aged 5XFAD mouse model of AD.