Expression of Salivary miRNA 21 in Oral Submucous Fibrosis (OSMF): An Observational Study.

Objective: To observe the expression patterns of salivary mRNA 21 in different stages and grades of OSMF and also in habitual areca nut chewers without OSMF.

Subjects And Methods: The study consisted of a total of 185 samples, where 61 patients had chewing habits (chewing gutkha and other forms of areca nut) and had OSMF (Group 1). 61 patients had chewing habits but did not have OSMF (Group 2), and 63 were normal healthy patients (control group) without any chewing habits (Group 3).

Assessment of epithelial-mesenchymal transition signatures in oral submucous fibrosis.

Background: Recently, the concept of field cancerization has questioned the accuracy of biopsy site selection clinically. Oral submucous fibrosis (OSMF) has a global malignant transformation rate of 7.6% despite having less dysplastic changes clinically or histologically.

Habit History in Oral Submucous Fibrosis: Have We Over Emphasized?

Aim: Correlation of habit duration and frequency with clinical grading and histopathologic grouping of oral submucous fibrosis (OSMF). Materials and methods: 48 patients with OSMF were included in the study. Detailed history of each patient, clinical profile and habit history were recorded.