Synopsis of recent research by authors named "Anisha Ambady"
- Anisha Ambady's recent research focuses on identifying novel antibacterial agents targeting various pathogens, particularly Mycobacterium tuberculosis, through combinatorial chemistry and structure-activity relationship studies.
- Her studies have led to the discovery of multiple lead compounds, such as benzimidazole-based DprE1 inhibitors and imidazo[1,2-a]pyridine ethers, demonstrating effectiveness in inhibiting mycobacterial ATP synthesis and showcasing improved solubility and potency.
- Ambady has also explored essential enzymes in bacterial survival, validating new drug targets such as topoisomerase I and phosphatidyl-myo-inositol mannosyltransferase PimA, while developing conditional expression systems for comprehensive target assessments.
