Publications by authors named "Anisa Dhana"
Article Synopsis
- This study explored the connection between blood pressure variability (BPV) and cognitive function in older adults, particularly focusing on those over 65 years old.
- Researchers analyzed data from 4,770 participants from the Chicago Health and Aging Project, measuring blood pressure every three years and assessing cognitive abilities through standardized tests.
- Results indicated that higher BPV was linked to lower cognitive scores, especially among older Black adults, suggesting that fluctuations in blood pressure could contribute to cognitive decline as people age.
Article Synopsis
- - Individuals with subjective memory complaints (SMCs) have higher levels of neurodegeneration biomarkers like neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP), indicating increased neurodegenerative processes.
- - The study involved 1,096 older adults and found that those with more memory complaints experienced a 12% increase in NfL and a 9.4% increase in GFAP compared to those with fewer complaints.
- - Participants reporting more memory issues also showed a faster cognitive decline, suggesting that SMCs could help identify individuals at higher risk for neurodegenerative conditions.
Article Synopsis
- Identifying high-risk individuals for Alzheimer's disease (AD) dementia allows for early intervention, which can prevent or delay the disease's onset.
- The study evaluated four AD dementia risk-prediction models using data from over 2,000 participants and found that the Brief Dementia Screening Indicator (BDSI) was the most effective for predicting risk in both Black and White adults.
- There is a need for race-specific risk models due to racial disparities in AD prevalence and the varying duration of disease development, especially as prediction accuracy diminishes over longer follow-up periods.
Background And Objectives: The association of statin initiation with incident Alzheimer disease (AD) dementia and cognitive decline by the ε4 allele is unknown. Our objective was to examine whether the association of statin initiation with incident AD dementia and cognitive decline differs by the ε4 allele.
Methods: This population-based longitudinal cohort study was conducted in 4 urban communities in Chicago, IL, United States, consisting of 4,807 participants.
Introduction: The aim of this study was to evaluate the association of cardiovascular health (CVH) with cognitive outcomes, including incident Alzheimer's dementia, rate of cognitive decline, and measures of brain injury and structure.
Methods: This study consisted of 1702 Black or African American and White participants living in the south side of Chicago, Illinois, and enrolled in the Chicago Health and Aging Project, a population-based cohort since 1993. CVH was based on seven risk factors, including diet, physical activity, body mass index, smoking, dyslipidemia, hypertension, and diabetes.
Neurofilament light chain (NfL), a neuron-specific protein, has been related to several neurodegenerative diseases. In addition, elevated levels of NfL have also been observed in patients admitted to the hospital for stroke, suggesting that NfL as a biomarker may extend well beyond neurodegenerative diseases. Therefore, using data from the Chicago Health and Aging Project (CHAP), a population-based cohort study, we prospectively investigated the association of serum NfL levels with incident stroke and brain infarcts.
View Article and Find Full Text PDFWhite matter hyperintensity, neurofilament light chain, and cognitive decline.
Ann Clin Transl Neurol
March 2023
Objective: We aimed to determine whether combining white matter hyperintensity (WMH) with neurofilament light chain (NfL) could provide additional information for cognition in older adults.
Methods: Utilizing data from the population-based Chicago Health and Aging Project, we studied 701 individuals with both biomarkers and cognitive data during the follow-up period. NfL was measured using an ultrasensitive immunoassay, single-molecule array technology.
Lifestyle and Cognitive Decline in Community-Dwelling Stroke Survivors.
J Alzheimers Dis
September 2022
Background: Patients with stroke are at a higher risk of cognitive impairment and Alzheimer's disease dementia.
Objective: To quantify the role of lifestyle pre-stroke, post-stroke, and changes in lifestyle before and after stroke with cognitive decline in community-dwelling stroke survivors.
Methods: Utilizing data from the Chicago Health and Aging Project, a population-based cohort study, we studied 1,078 individuals with stroke (662 incident and 416 prevalent) who underwent cognitive testing during the study period.
Introduction: To determine the role of vitamin D intake on cognitive decline among Blacks and Whites.
Methods: Using data from the population-based Chicago Health and Aging Project, we studied 2061 Blacks and 1329 Whites with dietary vitamin D data and cognitive testing over 12 years of follow-up. Multivariable linear mixed-effects models were used to determine the association of vitamin D intake with cognitive decline.
Importance: Subjective memory complaints (SMCs) are associated with a faster cognitive decline; whether this association is also associated with structural brain alterations, such as white matter hyperintensity (WMH) volumes, requires investigation.
Objective: To evaluate the association of SMCs with WMH volumes and cognitive decline and investigate the role of WMH volumes in the association between SMCs and cognitive decline.
Design, Setting, And Participants: The Chicago Health and Aging Project, a population-based cohort study, enrolled adults aged 65 years or older.
Objective: To determine the impact of lifestyle factors on life expectancy lived with and without Alzheimer's dementia.
Design: Prospective cohort study.
Setting: The Chicago Health and Aging Project, a population based cohort study in the United States.