Publications by authors named "Anis Cilic"
CEACAM6 as a Novel Therapeutic Target to Boost HO-1-mediated Antioxidant Defense in COPD.
Am J Respir Crit Care Med
June 2023
Article Synopsis
- Tobacco smoking and air pollution are major contributors to chronic obstructive pulmonary disease (COPD), yet not all smokers develop the condition, highlighting the need to explore protective mechanisms against oxidative stress.
- The study investigated various cohorts by analyzing sputum, lung tissue, and blood samples to measure levels of 3-nitrotyrosine (3-NT), an indicator of oxidative stress, and established a new cell model resistant to cigarette smoke extract (CSE) to understand the relationship between oxidative stress and COPD.
- Findings suggest that high levels of HO-1 (heme oxygenase-1) are linked to reduced oxidative stress in CSE-resistant cells, while increased expression of CEACAM6 in epithelial cells appears to exacerbate oxidative stress and
MicroRNAs (miRNAs) are short non-coding RNAs that function in post-transcriptional gene silencing and mRNA regulation. Although the number of nucleotides of miRNAs ranges from 17 to 27, they are mostly made up of 22 nucleotides. The expression of miRNAs changes significantly in cancer, causing protein alterations in cancer cells by preventing some genes from being translated into proteins.
View Article and Find Full Text PDFDetection of cytosine and CpG density in proto-oncogenes and tumor suppressor genes in promoter sequences of acute myeloid leukemia.
Nucleosides Nucleotides Nucleic Acids
April 2017
Aberrant methylation is one of the driving forces of cancer genome development. Although the rate of methylation appears massively variable across the genome, it is mainly observed in histone modification, chromatin organization, DNA accessibility, or promoter sequence. Methylation of promoter sequence occurs mostly to cytosine nucleotides, which can affect transcription factors' binding affinities.
View Article and Find Full Text PDFThe guanine rich locations are present in human genome. Previous studies have shown that the presence of G rich sequences and motifs may be significant for gene activity and function. We decided to focus our interest to identify G rich motifs in promoters of oncogenes and tumor suppressor genes.
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