Publications by authors named "Anis Abuseiris"
Article Synopsis
- The study investigates the three-dimensional architecture of human and mouse genomes, highlighting how this structure relates to genetic function, such as storage and expression of information.
- Using advanced techniques like high-resolution chromosomal interaction capture and polymer simulations, the research reveals that the genome is organized into a compact chromatin structure with stable loop formations that vary slightly between different cell types.
- The findings suggest that the genome's architecture is both stable and flexible, allowing for effective gene regulation and expression through self-organization, ultimately contributing to our understanding of genomic properties at a mechanical level.
The current fast growth of genome-wide association studies (GWAS) combined with now common computationally expensive imputation requires the online access of large user groups to high-performance computing resources capable of analyzing rapidly and efficiently millions of genetic markers for ten thousands of individuals. Here, we present a web-based interface--called GRIMP--to run publicly available genetic software for extremely large GWAS on scalable super-computing grid infrastructures. This is of major importance for the enlargement of GWAS with the availability of whole-genome sequence data from the 1000 Genomes Project and for future whole-population efforts.
View Article and Find Full Text PDFThe sequential organization of genomes, i.e. the relations between distant base pairs and regions within sequences, and its connection to the three-dimensional organization of genomes is still a largely unresolved problem.
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