Self-assembled sustainable bionanocomposite hydrogels from chitosan for the combination chemotherapy of hydrophobic and hydrophilic drugs.

Self-assembled hydrogels derived from naturally sourced polymers have gained significant interest in drug delivery applications, owing to their potential, exceptional biocompatibility and sustainable properties. This work presents the development and application of self-assembled nanocomposite hydrogels from chitosan and nanosilver as a pH responsive drug delivery system for the controlled release of doxorubicin and paclitaxel in anticancer therapy. Chitosan was functionalized with 4-formyl benzoic acid for incorporating both hydrophobic and hydrophilic anticancer drugs.

A Self-Skin Permeable Doxorubicin Loaded Nanogel Composite as a Transdermal Device for Breast Cancer Therapy.

Modern drug delivery research focuses on developing biodegradable nanopolymer systems. The present study proposed a polymer-based composite nanogel as a transdermal drug delivery system for the pH-responsive targeted and controlled delivery of anticancer drug doxorubicin (DOX). Nanogels have properties of both hydrogels and nanomaterials.

Molecularly imprinted nanoparticles doped graphene oxide based electrochemical platform for highly sensitive and selective detection of L-tyrosine.

A highly sensitive and selective electrochemical sensor was developed using a surface modified glassy carbon electrode (GCE) through molecularly imprinted polymerization on the surface of vinyltrimethoxysilane (VTMS) coated magnetic nanoparticle (FeO) decorated silver nanoparticles incorporated graphene oxide, GO (VTMS-FeO/AgGO) for L- Tyrosine (Tyr) detection. A molecular imprinting technique based on free radical polymerization was applied to synthesize molecularly imprinted Methacrylic acid (MAA) and Acrylamide (AA) grafted VTMS-FeO/AgGO polymer (MAA/AA-g- VTMS-FeO/AgGO) designated as MIP and non-imprinted polymer (NIP). The structure and morphology of the prepared polymers were FTIR, XRD, FE-SEM and VSM.

Magnetic nanoparticle embedded chitosan-based polymeric network for the hydrophobic drug delivery of paclitaxel.

Safe delivery of hydrophobic drugs to the tumor site is a major problem for the scientific community. To improve the in vivo efficacy of hydrophobic drugs by avoiding solubility concerns and providing targeted delivery by nanoparticle, we have developed robust iron oxide nanoparticles coated chitosan with ([2- (methacryloyloxy) ethyl] trimethyl ammonium chloride) (METAC) [CS-IONPs-METAC-PTX] as a drug carrier for the delivery of hydrophobic drug, paclitaxel (PTX). Drug carrier was characterized using various techniques like FT-IR, XRD, FE-SEM, DLS and VSM.

Detection of chlorpyrifos based on molecular imprinting with a conducting polythiophene copolymer loaded on multi-walled carbon nanotubes.

Molecular imprinting technique (MIT) with electrochemical sensing provides an attractive tool for the fabrication of sensors. Incorporation of conducting copolymer and surface imprinting strategies in the sensing device improves the conducting properties and poor template accessibility, slow binding kinetics at the same time. Here, this technique was employed with conducting polymers with multi-walled carbon nanotubes (MWCNT) to build an electrochemical sensor for detecting Chlorpyrifos (CPF) in vegetable sample solutions.

Modified chitosan-hyaluronic acid based hydrogel for the pH-responsive Co-delivery of cisplatin and doxorubicin.

Combination chemotherapy has attracted more attention in the field of anticancer treatment due to the synergetic effects achieved in the targeted delivery of anticancer drugs. In the present work a hydrogel-based drug delivery system (CS-NSA/A-HA) was successfully developed from chitosan modified by nitrosalicylaldehyde and aldehyde hyaluronic acid. Anticancer drugs, Cisplatin (CDDP) and Doxorubicin (DOX) were incorporated into this hydrogel separately and a dual drug loaded system was synthesized and the potential of the single and dual drug loaded materials for lung cancer therapy was compared.

Hyaluronic acid coated Pluronic F127/Pluronic P123 mixed micelle for targeted delivery of Paclitaxel and Curcumin.

The hydrophobicity of most of the anticancer drugs offers a great challenge in selecting a system for their effective transport. Here comes the importance of micelles that offers a hydrophobic core for incorporating these drugs. In this study, Hyaluronic Acid coated Pluronic mixed micelle loaded with Paclitaxel and Curcumin was designed and evaluated its anticancer activity in MCF-7 cells.

A new biodegradable nano cellulose-based drug delivery system for pH-controlled delivery of curcumin.

Targeted delivery and controlled release of drugs are attractive methods for avoiding the drug's leakage during blood circulation and burst release of the drug. We prepared a nano cellulose-based drug delivery system (DDS) for the effective delivery of curcumin (CUR). In the present scenario, the role of nanoparticles in fabricating the DDS is an important one and was characterized using various techniques.

Graphene oxide based functionalized chitosan polyelectrolyte nanocomposite for targeted and pH responsive drug delivery.

Graphene oxide (GO) was first modified to amine functionalized GO (AGO) and acts as a cationic polyelectrolyte. Chitosan (CS) was conjugated with folic acid (FA) through N, N´ -Dicyclohexylcarbodiimide coupling to form FA-CS. After this, itaconic acid and acrylic acid monomers are grafted to the hydroxyl group of CS using ethyleneglycol dimethacrylate as cross linker and potassium peroxydisulfate as an initiator to generate -COOH functional groups and forming chemically modified chitosan (CMCS).

Development of voltage gated transdermal drug delivery platform to impose synergistic enhancement in skin permeation using electroporation and gold nanoparticle.

Owing to poor skin permeability, the transdermal (TRD) drug delivery at the required therapeutic rate still remains an arduous task. In the present investigation, a novel TRD enhancement strategy was introduced using the synergistic effect of gold nanoparticle (GNP) and skin electroporation. Diclofenac sodium (DS) was selected as a model drug.

Synthesis and characterization of amidoxime modified chitosan/bentonite composite for the adsorptive removal and recovery of uranium from seawater.

A novel amidoxime functionalized adsorbent, poly(amidoxime)-grafted-chitosan/bentonite composite [P(AO)-g-CTS/BT] was prepared by in situ intercalative polymerization of acrylonitrile (AN) and 3-hexenedinitrile (3-HDN) onto chitosan/bentonite composite using ethylene glycol dimethacrylate (EGDMA) as cross linking agent and potassium peroxy disulphate (KSO) as free radical initiator. The adsorbent was characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), Energy dispersive spectroscopy (EDS), BET surface area analyser and X-ray photoelectron spectroscopy (XPS). Nitrile groups from two monomers converted to amidoxime groups and therefore, increases the adsorption efficiency of uranium(VI) [U(VI)] from seawater.

Gold Nanoparticle and Hydrophobic Nanodiamond Based Synergistic System: A Way to Overcome Skin Barrier Function.

Gold nanoparticles (AuNP) have attracted ample attention as a transdermal (TND) drug delivery platform for improving the skin permeability of drug molecules. Herein a novel TND device formed from AuNP and oleylamine functionalized nanodiamond (AuD) has been developed successfully for the TND delivery of Ketoprofen (KP), a model drug. Poly(vinyl alcohol)/Polybutyl methacrylate (PVA/PBMA) film has been selected as the matrix of the TND device, as they furnish excellent skin adhesion properties.

Electrochemical sensing of cholesterol by molecularly imprinted polymer of silylated graphene oxide and chemically modified nanocellulose polymer.

Silylated Graphene oxide-grafted-chemically modified nanocellulose (Si-GO-g-CMNC) is fabricated for selective sensing of Cholesterol. Zinc oxide (ZnO) incorporated in chemically modified nanocellulose (CMNC) for enhancing the conducting nature. The sensitivity of sensor was checked by modifying the glassy carbon electrode surface (GCE) with Si-GO-g-CMNC and the electro chemical studies were conducted with cyclic voltammetry (CV) and differential pulse voltammetry (DPV).

Novel pH sensitive dual drug loaded-gelatin methacrylate/methacrylic acid hydrogel for the controlled release of antibiotics.

The aim of the present study was to develop a novel pH sensitive gelatin methacrylate hydrogel for the controlled delivery of Gentamicin (GS) and Ampicillin (Amp). GS and Amp having synergistic activity is effective in killing multi drug resistant bacteria. The hydrogel was well characterized using FTIR, XRD and SEM techniques.

Temperature and ultrasound sensitive gatekeepers for the controlled release of chemotherapeutic drugs from mesoporous silica nanoparticles.

With the advent of smart biomaterials, environmental stimuli have always been the trigger for targeted drug delivery. Conventional routes of drug administration suffer from serious drawbacks like first pass metabolism, less patient compliance and the requirement of trained personnel. Of the many well-established non-conventional routes, transdermal drug delivery systems (TDDSs) seem to be promising as they do not enter directly into the bloodstream and hence, side effects can significantly be reduced.

Methacrylate-Stitched β-Cyclodextrin Embedded with Nanogold/Nanotitania: A Skin Adhesive Device for Enhanced Transdermal Drug Delivery.

Transdermal (TD) drug delivery is a more attractive technique for drug delivery compared to oral and intravenous injection. However, the permeation of drug molecules across the skin is difficult due to the presence of highly ordered lipid barrier. This study details the development of a novel TD system, which has the potential to simultaneously enhance the skin permeability and adhesion behavior.

The role of biopolymer matrix films derived from carboxymethyl cellulose, sodium alginate and polyvinyl alcohol on the sustained transdermal release of diltiazem.

Due to changing lifestyles of modern world, cardiac failures are increasing day by day. Drug delivery systems that can overcome the drawbacks of conventional drug administration are highly desired. Diltiazem hydrochloride (DTZ) is a common and effective drug used for cardiac failures.

Nanoparticle assisted solvent selective transdermal combination therapy of curcumin and 5-flurouracil for efficient cancer treatment.

Skin cancer is one among the many prominent diseases of the modern world and millions of people are suffering due to the lack of proper medication. Even though transdermal drug delivery systems (TDDS) provide an efficient route of drug administration, the advantages of combination chemotherapy have rarely been extended into TDDS. In the present work, a polymer capable of simultaneously encapsulating two anti-cancer drugs: 5-flurouracil (5-FU) and curcumin (CUR), and releasing them with varying kinetics as a function of the leaching solvent was developed.

Synthesis characterization and biological evaluation of alginate nanoparticle for the targeted delivery of curcumin.

Cancer continues to be a serious disaster to mankind. Chemotherapy is an efficient and effective treatment against cancer. Lack of selectivity is the main challenge faced by chemotherapy.

Extraction of melamine from milk using a magnetic molecularly imprinted polymer.

A novel magnetic molecularly imprinted polymer (MMIP) for the preconcentration of melamine, a non-protein nitrogen food additive from complex matrices was synthesized and characterized using FT-IR, XRD, SEM and VSM techniques. Surface imprinting was done on vinyltrimethoxysilane coated FeO (FeO-VTMS) using 2-acrylamido-2-methylpropane sulfonic acid (AMPS), N,N'-methylenebisacrylamide (MBA) and potassium persulfate (KPS) as functional monomer, crosslinker and initiator respectively. Saturation magnetization value obtained for MMIP was 1.

Nano-zinc oxide incorporated graphene oxide/nanocellulose composite for the adsorption and photo catalytic degradation of ciprofloxacin hydrochloride from aqueous solutions.

Purpose of this study is to report the synthetic procedure of a novel photo catalyst, nano zinc oxide incorporated graphene oxide/nanocellulose (ZnO-GO/NC) for the effective adsorption and subsequent photo degradation of ciprofloxacin (CF), an antibiotic widely used in the poultry. Self cleaning property in cellulose was achieved by introducing a nano zinc oxide incorporated graphene oxide into nanocellulose (NC) matrix. By incorporating nano zinc oxide (ZnO) in graphene oxide (GO), band gap could be tuned to 2.

Synthesis and characterization of polyacrylic acid- grafted-carboxylic graphene/titanium nanotube composite for the effective removal of enrofloxacin from aqueous solutions: Adsorption and photocatalytic degradation studies.

Polyacrylic acid-grafted-carboxylic graphene/titanium nanotube (PAA-g-CGR/TNT) composite was synthesized. It was effectively used as adsorbent as well as photocatalyst. The composite was characterized by FTIR, XRD, SEM, TEM, Surface Area Analyzer, XPS and DRS.

Extended wear therapeutic contact lens fabricated from timolol imprinted carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-poly acrylamide as a onetime medication for glaucoma.

An extended wear therapeutic contact lens (TCL) for the sustained delivery of timolol maleate (TML) was fabricated based on molecular imprinting technique. The designed TCL comprised of a TML imprinted copolymer of carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-polyacrylamide (CmCS-g-HEMA-g-pAAm) embedded onto a poly HEMA matrix (pHEMA). Successful reloading of TML onto the lens was monitored using a simple and novel UV-Visible spectrophotometric method which showed an excellent reloading capacity of 6.

Fabrication of a bioadhesive transdermal device from chitosan and hyaluronic acid for the controlled release of lidocaine.

A novel efficient transdermal (TD) lidocaine (LD) delivery device based on chitosan (CS) and hyaluronic acid (HA) was successfully developed in the present investigation. CS was grafted with glycidyl methacrylate (GMA) and butyl methacrylate (BMA) to fabricate a versatile material with improved adhesion and mechanical properties. HA was hydrophobically modified by covalently conjugating 3-(dimethylamino)-1-propylamine (DMPA) to encapsulate poorly water soluble LD and was uniformly dispersed in modified CS matrix.

Enzyme coated beta-cyclodextrin for effective adsorption and glucose-responsive closed-loop insulin delivery.

Inconsistent dosage of insulin (INS) for type 2 diabetes patients lead to severe adverse effects like limb amputation, blindness and fatal hypo or hyper glycaemia. Hence, a drug delivery system (DDS) capable of consistent INS release by sensing changes in blood glucose level is essential. Herein, we report a glucose responsive DDS comprised of oleic acid-grafted-aminated beta cyclodextrin (OA-g-ACD) copolymer, coated with a dispersion of glucose oxidase (GOx) and catalase (CAT).