Factors Promoting Lipopolysaccharide Uptake by Synthetic Lipid Droplets.

Lipoproteins are essential in removing lipopolysaccharide (LPS) from blood during bacterial inflammation. The physicochemical properties of lipoproteins and environmental factors can impact LPS uptake. In this work, synthetic lipid droplets containing triglycerides, cholesterols, and phospholipids, were prepared to mimic lipoproteins.

Recent Developments in Drug Delivery for Treatment of Tuberculosis by Targeting Macrophages.

Tuberculosis (TB) is among the greatest public health and safety concerns in the 21 century, which causes TB, infects alveolar macrophages and uses these cells as one of its primary sites of replication. The current TB treatment regimen, which consist of chemotherapy involving a combination of 3-4 antimicrobials for a duration of 6-12 months, is marked with significant side effects, toxicity, and poor compliance. Targeted drug delivery offers a strategy that could overcome many of the problems of current TB treatment by specifically targeting infected macrophages.

Hetero-Multivalent Targeted Liposomal Drug Delivery to Treat Infections.

is the leading nosocomial and community-acquired pathogen causing a plethora of acute and chronic infections. The Centers for Disease Control and Prevention has designated multidrug-resistant isolates of as a serious threat. A novel delivery vehicle capable of specifically targeting  , and encapsulating antimicrobials, may address the challenges associated with these infections.