Repairing the Nasal Valve in Revision Surgery.

Nasal airway obstruction is a frequent complaint in an otolaryngology clinic and is often multifactorial. Anatomic contributors may include a nasal septal deviation, inferior turbinate hypertrophy, and nasal valve compromise. Septoplasty and inferior turbinate reduction are one of the most common procedures performed by an otolaryngologist.

Assessing the Quality of Social Media Content Regarding Facial Paralysis and Reanimation.

Patients frequently use social media to direct their health care. However, the quality of social media posts regarding facial paralysis and reanimation is unclear. To assess the quality of facial reanimation posts on social media.

Surgery-Related Considerations in Treating People Who Use Cannabis: A Review.

Importance: Cannabis use has experienced substantial growth. Many patients treated by otolaryngologists are using cannabis in various forms, often without the knowledge of the treating surgeon. These cannabinoid substances have various systemic effects, and it is critical for otolaryngologists to recognize how cannabis use may contribute to a patient's care.

The effect of cannabinoids on wound healing: A review.

Background And Aims: Cannabis and its various derivatives are commonly used for both recreational and medicinal purposes. Cannabinoids have been shown to have anti-inflammatory properties. Inflammation is an important component of wound healing and the effect of cannabinoids on wound healing has become a recent topic of investigation.

Cadaveric Assessment of the Butterfly Graft in Rhinoplasty.

Introduction: The rhinoplasty butterfly graft is used to improve the internal nasal valve (INV), but post-operative visibility remains a concern. Intraoperative techniques have developed to thin the graft with unknown effect on functionality.

Objectives: Improve understanding of how to modify the aesthetics of the butterfly graft without impacting patient outcomes.

SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of crossover recombination intermediates during mammalian meiosis.

Chromosome segregation errors during meiosis result in the formation of aneuploid gametes and are the leading cause of pregnancy loss and birth defects in humans. Proper chromosome segregation requires pairwise associations of maternal and paternal homologous chromosomes. Chiasmata, which are the cytological manifestations of crossovers (COs), provide a physical link that holds the homologs together as a pair, facilitating their orientation on the spindle at meiosis I.

FXN Promoter Silencing in the Humanized Mouse Model of Friedreich Ataxia.

Background: Friedreich ataxia is caused by an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene that results in epigenetic silencing of the FXN promoter. This silencing mechanism is seen in patient-derived lymphoblastoid cells but it remains unknown if it is a widespread phenomenon affecting multiple cell types and tissues.

Methodology / Principal Findings: The humanized mouse model of Friedreich ataxia (YG8sR), which carries a single transgenic insert of the human FXN gene with an expanded GAA triplet-repeat in intron 1, is deficient for FXN transcript when compared to an isogenic transgenic mouse lacking the expanded repeat (Y47R).