Targeted NIR Fluorescent Mechanically Interlocked Molecules-Peptide Bioconjugate for Live Cancer Cells Submitochondrial Stimulated Emission Depletion Super-Resolution Microscopy.

Herein, a water-soluble, ultrabright, near-infrared (NIR) fluorescent, mechanically interlocked molecules (MIMs)-peptide bioconjugate is designed with dual targeting capabilities. Cancer cell surface overexpressed αβ integrin targeting two RGDS tetrapeptide residues is tethered at the macrocycle of MIMs-peptide bioconjugate via Cu(I)-catalyzed click chemistry on the Wang resin, and mitochondria targeting lipophilic cationic TPP functionality is conjugated at the axle dye. Living carcinoma cell selective active targeting, subsequently cell penetration, mitochondrial imaging, including the ultrastructure of cristae, and real-time tracking of malignant mitochondria by MIMs-peptide bioconjugate (RGDS)-Mito-MIMs-TPP are established by stimulated emission depletion (STED) super-resolved fluorescence microscopy.

Challenges and opportunities in engineering next-generation 3D microelectronic devices: improved performance and higher integration density.

In recent years, nanotechnology and materials science have evolved and matured, making it increasingly easier to design and fabricate next-generation 3D microelectronics. The process has changed drastically from traditional 2D microelectronics, resulting in improved performance, higher integration density, and new functionalities. As applications become more complex and power-intensive, this technology can address the demands of high-performance computing, advanced sensors, and cutting-edge communication systems wearable, flexible devices, To manufacture higher-density microelectronics, recent advances in the fabrication of such 3D devices are discussed.

A mitochondria targeting, designed, aggregation-induced emission probe for selective detection of neurotoxic amyloid-β aggregates.

A striking issue is the scarcity of imaging probes for the early diagnosis of Alzheimer's disease. For the development of Aβ biomarkers, a mitochondria targeting, designed, aggregation-induced emission (AIE) probe Cou-AIE-TPP is constructed by engineering the aromatic coumarin framework into the bridge of electron donor-acceptor-donor tethered with a lipophilic cationic triphenylphosphonium (TPP) group. The synthesized Cou-AIE-TPP probe exhibits biocompatibility, noncytotoxicity, and a huge Stokes shift (124 nm in PBS).

Design of an Acidic pH-Activated NIR Fluorescent Convertible Rhodamine-Hemicyanine Probe-Peptide Conjugate for Living Cancer Cell Active Targeted Selective Tracking of Lysosomes.

We have synthesized an acidic pH-activatable dual targeting ratiometric fluorescent probe-peptide conjugate using the SPPS protocol on Rink amide AM resin. Living carcinoma cell specific active targeting, successive cell penetration, and selective staining of lysosomes are accomplished. Real-time monitoring of lysosomes, 3D, and multicolor cancer cell imaging are also attained.

Catharanthus roseus-mediated CuAlO nanocomposites for evaluation of killing kinetics.

The present article portrayed on the killing kinetic of human pathogenic bacteria using bioinspired mesoporous CuAlO nanocomposites (NCs). The NCs was fabricated using leaf extract of medicinal plant Catharanthus roseus (CR) as a green reducer and stabilizer. As bio-fabricated material was calcined at 800 °C and characterized by several analytical techniques like X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FT-IR), Ultraviolet-Visible Diffuse Reflectance Spectroscopy (UV-DRS), Energy Dispersive X-Ray Spectroscopy (EDS), X-Ray Photoelectron Spectroscopy (XPS), Raman, Brunauer-Emmett-Teller (BET), Scanning Electron Microscopy (SEM), and Transmission Electron Microscopy (TEM) to authenticate its structure, phase, chemical bonding, chemical state, size and morphology behaviors.

CZTS (CuZnSnS)-based Nanomaterials in Photocatalytic and Hydrogen Production Applications: A Recent Progress towards Sustainable Environment.

A variety of unique compounds have been examined to accommodate the current demand for useful multi-functional nanomaterials, copper-based quaternary CZTS semiconductors are one of them. Due to their special characteristic features like non-toxicity, cheap, and abundance, they have been recommended in recent literature for various applications. Apart from individual CZTS, different hetero-structures have also been prepared with different compounds which is well discussed and elaborated in this article.

Design of Water-Soluble Rotaxane-Capped Superparamagnetic, Ultrasmall FeO Nanoparticles for Targeted NIR Fluorescence Imaging in Combination with Magnetic Resonance Imaging.

Integrating an NIR fluorescent probe with a magnetic resonance imaging (MRI) agent to harvest complementary imaging information is challenging. Here, we have designed water-soluble, biocompatible, noncytotoxic, bright-NIR-emitting, sugar-functionalized, mechanically interlocked molecules (MIMs)-capped superparamagnetic ultrasmall FeO NPs for targeted multimodal imaging. Dual-functional stoppers containing an unsymmetrical NIR squaraine dye interlocked within a macrocycle to construct multifunctional MIMs are developed with enhanced NIR fluorescence efficiency and durability.

A novel supramolecular Zn(ii)-metallogel: an efficient microelectronic semiconducting device application.

A unique strategy for the synthesis of a supramolecular metallogel employing zinc ions and adipic acid in DMF medium has been established at room temperature. Rheological analysis was used to investigate the mechanical characteristics of the supramolecular Zn(ii)-metallogel. Field emission scanning electron microscopy and transmission electron microscopy were used to analyse the hexagonal shape morphological features of the Zn(ii)-metallogel.

Preparation of mesoporous ThO nanoparticles: Influence of calcination on morphology and visible-light-driven photocatalytic degradation of indigo carmine and methylene blue.

The present article reports the synthesis of thoria nanoparticles (ThO NPs) via sol-gel process and examines the effect of calcination temperature of ThO on the morphology and photocatalytic degradation of indigo carmine (IC) and methylene blue (MB) under visible-light. As-synthesized white crystals of ThO were subjected to calcination at different temperatures, viz. 700 °C (TH-700), 800 °C (TH-800), and 900 °C (TH-900).

Biosynthesized δ-BiO Nanoparticles from Flower Extract for Photocatalytic Dye Degradation and Molecular Docking.

Bioinspired delta-bismuth oxide nanoparticles (δ-BiO NPs) have been synthesized using a greener reducing agent and surfactant co-precipitation method. The originality of this work is the use of flower extract for the first time for the fabrication of NPs, which were further calcined at 800 °C to obtain δ-BiO NPs. Physicochemical studies such as FTIR spectroscopy and XPS confirmed the formation of BiO NPs, whereas XRD and Raman verified the formation of the cubic delta (δ) phase of BiO NPs.

A naturally fluorescent protein C-phycoerythrin and graphene oxide bio-composite as a selective fluorescence 'turn off/on' probe for DNA quantification and characterization.

Highly specific graphene-DNA interactions have been at the forefront of graphene-based sensor design for various analytes, including DNA itself. However, in addition to its detection, DNA also needs to be characterized according to its size and concentration in a sample, which is an additional analytical step. Designing a highly sensitive and selective DNA sensing and characterization platform is, thus, of great interest.

Biogenic Synthesis of Metal/Metal Oxide Nanostructured Materials.

Nanotechnology is an emerging outlet of nanoscience in which the atoms are encompassed in nanoscale dimensions and become more receptive compared with their distinctive counterparts. Recently, the utilization of synthetic designs and physicochemical approaches has received special attention; nevertheless, the generation of noxious impressions on the eco-system has raised serious concerns of the scientific community worldwide. Presently, environment-friendly green synthesis routes are promising venues for the arrangement of Metal/Metal Oxide (M/MO) nanostructured materials by using plants and their corresponding alliances.

Bioinspired Reduced Graphene Oxide Based Nanohybrids for Photocatalysis and Antibacterial Applications.

Ultra-thin graphene has been receiving significance in the diverse sections of material science, owing to its exceptional physicochemical and thermo-mechanical characteristics. Currently, the fabrication of high-grade graphene in an economical target and green procedures area is a massive concern. Among the diverse techniques, chemical-mediated fabrication is believed to be the finest process since it is simple, scalable, and of low-cost; however, it involves noxious or hazardous chemical reducers for producing functional graphene-based Nanocomposites (NCs).

Sub 10 nm CoO nanoparticle-decorated graphitic carbon nitride for solar hydrogen generation efficient charge separation.

Solar hydrogen generation is one of the most compelling concepts in modern research to address both the energy and environmental issues simultaneously for the survival of the human race. A Type II heterojunction (CoO-GCN) was fabricated by decorating sub 10 nm CoO nanoparticles (NPs) on the graphitic carbon nitride (GCN) surface. It exhibited improved absorption of UV-VIS light and efficiently separate the photogenerated electrons and holes in opposite directions.

A 'one-tube' synthesis of a selective fluorescence 'turn off/on' DNA probe based on a C-phycocyanin-graphene oxide (CPC-GO) bio composite.

A naturally fluorescent protein, C-phycocyanin (CPC), was used as a fluorophore to study the effect of graphene oxide (GO) as a quencher. The protein was purified using established procedures and titrated with increasing GO concentrations. UV-visible titration showed a minor effect on the phycocyanobilin absorbance but significant interactions with the amino acid backbone.

Mesoporous Octahedron-Shaped Tricobalt Tetroxide Nanoparticles for Photocatalytic Degradation of Toxic Dyes.

The present article reports a facile approach to fabrication of mesoporous octahedron-shaped tricobalt tetroxide nanoparticles (CoO NPs) with a very narrow size distribution for eco-friendly remediation of toxic dyes. CoO NPs were fabricated by a solgel process using cobalt chloride hexahydrate (CoCl·6HO) and monosodium succinate (CHONa) as a chelating/structure-directing agent and sodium dodecyl sulfate as a surfactant. Moreover, the phase structure, elemental composition, and thermal and morphological facets of CoO NPs were investigated using XRD, FT-IR, EDS, Raman, XPS, TGA, SEM, and TEM techniques.

Enhanced Photodetection with Crystalline Si Nanoclusters.

SiO nanodots were fabricated on a TiO₂ thin film using glancing angle deposition technique. The fabricated samples were annealed at 950 °C in open air configuration to obtain Si nanoclusters resulting from phase separation of SiO nanodots. Field Emission Gun Scanning electron microscopy and atomic force microscopy were used to examine the topography of the samples.

Bipolar Analog Memristive Switching of In₂O₃ Using Al Nanoparticles.

Aluminum nanoparticles (AlNPs) were embedded into a sol-gel synthesized In₂O₃ thin film by using a combination of thermal evaporation and glancing Angle Deposition technique. Presence of different sizes of aluminum nanoparticles was confirmed from field emission gun scanning electron microscopy. The high-resolution X-ray diffraction confirms the formation of Al₂O₃ NPs by surface oxidation of aluminum nanoparticles.

Highly Active Ultrasmall Ni Nanoparticle Embedded Inside a Robust Metal-Organic Framework: Remarkably Improved Adsorption, Selectivity, and Solvent-Free Efficient Fixation of CO.

We report integrating additional functionality in an amine decorated, robust metal-organic framework (MOF) by encapsulating Ni nanoparticles (NPs). In-depth characterization of the postmodified structure confirms well-dispersed and ultrasmall NPs inside the framework pores. Although, the surface area is more reduced than pristine MOF, the CO uptake capacity is remarkably increased by 35% with a large 10 kJ/mol rise in adsorption enthalpy that validates favorable interactions between CO and NPs.

Phytosynthesis of nearly monodisperse CuO nanospheres using Phyllanthus reticulatus/Conyza bonariensis and its antioxidant/antibacterial assays.

In the present article we have developed an eco-friendly, phytosynthetic, cost-effective and straightforward method for the synthesis of nearly monodisperse CuO nanospheres (NSP) using leaf extracts of medicinal plants Phyllanthus reticulatus (PR) and Conyza bonariensis (CB) as novel green reducing agents. Copper nitrate (Cu (NO)) was used as a precursor. The stoichiometric ratio of both leaf extracts (PR/CB) and Cu(NO) was standardized for the synthesis of NSP.

Effect of Ag Doping on the Glancing Angle Deposition Synthesized TiO₂ Nanowire for Enlarged Photodetection.

Glancing Angle Deposition (GLAD) technique was employed to synthesize Ag doped TiO2 nanowire on n-type Si-substrate. FEG-SEM confirms the perpendicular growth of Ag doped TiO2 nanowire with an average height and diameter of ~554 nm and ~40 nm respectively. The composition analysis by EDAX indicates the presence of Ti, O, Si and Ag elements.

Improved UV Photodetection by Indium Doped TiO₂ Thin Film Based Photodetector.

Indium (In) was doped into TiO2 thin film (TF) using the electron beam evaporation technique followed by an annealing process. The high resolution X-ray diffraction (HRXRD) analysis revealed lower angle diffraction peak (2) shifting of Rutile (002) phases of TiO2 from 61.9 to 61.

Visible-light-driven Efficient Photocatalytic Reduction of Organic Azides to Amines over CdS Sheet-rGO Nanocomposite.

CdS sheet-rGO nanocomposite as a heterogeneous photocatalyst enables visible-light-induced photocatalytic reduction of aromatic, heteroaromatic, aliphatic and sulfonyl azides to the corresponding amines using hydrazine hydrate as a reductant. The reaction shows excellent conversion and chemoselectivity towards the formation of the amine without self-photoactivated azo compounds. In the adopted strategy, CdS not only accelerates the formation of nitrene through photoactivation of azide but also enhances the decomposition of azide to a certain extent, which entirely suppressed formation of the azo compound.

High Internal Gain Axial SiOx-In2-xO3-y/Au Heterostructure Nanocolumnar Array Based Schottky Detector for Broad Band Recognition.

Glancing angle deposition (GLAD) was employed to fabricate the SiOx-In2-xO3-y axial heterostructure nanocolumn. The fabricated heterostructure nanocolumn was annealed at 550 °C for 1 hour at open air condition. The XRD analysis revealed the polycrystalline nature of the annealed SiOx-In2-xO3-y nanocolumn.

Visible light induced synthesis of fluorescent silver clusters in reverse micelles.

A light-induced reverse micelle mediated method was developed for the preparation of stable Ag clusters in high yield. The clusters exhibit a molecule-like UV-Vis spectrum consisting of five absorption bands, emit red fluorescence and have chiroptical properties.