Population-level coding of avoidance learning in medial prefrontal cortex.

The medial prefrontal cortex (mPFC) has been proposed to link sensory inputs and behavioral outputs to mediate the execution of learned behaviors. However, how such a link is implemented has remained unclear. To measure prefrontal neural correlates of sensory stimuli and learned behaviors, we performed population calcium imaging during a new tone-signaled active avoidance paradigm in mice.

Residual dynamics resolves recurrent contributions to neural computation.

Relating neural activity to behavior requires an understanding of how neural computations arise from the coordinated dynamics of distributed, recurrently connected neural populations. However, inferring the nature of recurrent dynamics from partial recordings of a neural circuit presents considerable challenges. Here we show that some of these challenges can be overcome by a fine-grained analysis of the dynamics of neural residuals-that is, trial-by-trial variability around the mean neural population trajectory for a given task condition.