Robust Response to Futibatinib in a Patient With Metastatic FGFR-Addicted Cholangiocarcinoma Previously Treated Using Pemigatinib.

Futibatinib is a novel FGFR inhibitor currently under investigation as a second-line treatment for locally advanced or metastatic cholangiocarcinoma harboring FGFR2 gene fusions and rearrangements. As FGFR-targeted therapies move into the frontline setting, sequencing of these drugs remains undetermined. To date, no study has investigated the use of futibatinib in the context of pemigatinib resistance.

Concurrent ophthalmomyiasis externa and aural myiasis: A case report in an urban hospital in the United States.

Purpose: To describe a case of concurrent ophthalmomyiasis externa and aural myiasis in a patient presenting with headache, right eye pain and blurred vision in an urban hospital in Philadelphia, PA.

Observations: Myiasis is the parasitic infestation of a live mammal with fly larvae that feed and grow on host tissue. Predominantly described in the Middle East, Africa and Asia, it is rarely reported in the United States.

An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet.

Recent studies have shown cytoplasmic droplets to be normal morphological occurrences in human male spermatozoa. When the cytoplasm around the sperm midpiece is present in large amounts, however, pathological effects may transpire. The cytoplasmic droplet then becomes known as excess residual cytoplasm, which can impair overall sperm function and produce higher levels of reactive oxygen species, potentially leading to male infertility.