Impact of Cryogenic Treatment on HCF and FCP Performance of β-Solution Treated Ti-6Al-4V ELI Biomaterial.

The poor fatigue strength of Ti-6Al-4V ELI is a main cause of failure in structural implants. In this work, Ti-6Al-4V ELI was subjected to β-solution treatment to obtain martensite microstructure and further subjected to -196 °C for 24 h. Significant improvement in high cycle fatigue performance of martensite Ti-6Al-4V ELI was observed on exposure to cryogenic cycle.

Abrasive Wear Behavior of Cryogenically Treated Boron Steel (30MnCrB4) Used for Rotavator Blades.

Rotavator blades are prone to significant wear because of the abrasive nature of sand particles. The aim of this research work is to investigate the effect of cryogenic treatment and post tempering on abrasive wear behavior, in the presence of angular quartz sand (grain size of 212-425 μm), of rotavator blade material of boron steel (30MnCrB4). Cryogenic treatment has caused an improvement in the abrasive wear resistance and microhardness of 30MnCrB4 by 60% and 260.

Bioavailability of immediate- and extended-release formulations of glipizide in healthy male volunteers.

Background And Objective: An extended-release glipizide formulation using a hydrophilic matrix system containing hydrophilic polymers has been developed for use in diabetes mellitus. This study compared the pharmacokinetic parameters of immediate- and extended-release formulations of glipizide 5mg in healthy male volunteers.

Methods: In a single-dose, four-period, four-treatment, Latin-square crossover study, the bioavailability of immediate-release glipizide 5mg (Glynase) [GL], extended-release glipizide 5mg (Glynase) XL [GLXL], Glucotrol XL [GTXL], and the new formulation developed in our laboratory [GLPF]) was compared.

Evaluation of mucoadhesive properties of chitosan microspheres prepared by different methods.

The mucoadhesive properties of chitosan microspheres prepared by different methods were evaluated by studying the interaction between mucin and microspheres in aqueous solution. The interaction was determined by the measurement of mucin adsorbed on the microspheres. A strong interaction between chitosan microspheres and mucin was detected.