Synopsis of recent research by authors named "Anil Aktas Samur"
- Anıl Aktas Samur's research primarily focuses on the genetic and molecular mechanisms underlying multiple myeloma (MM), exploring areas such as venetoclax resistance, mutational impacts of high-dose melphalan, and the splicing landscape of MM cells to uncover therapeutic vulnerabilities.
- The recent findings indicate that venetoclax resistance leads to widespread resistance against standard treatments for MM, though immunotherapies may remain effective; additionally, significant mutational burdens at relapse following high-dose melphalan suggest implications for treatment strategies.
- Other key insights from his studies include the role of long noncoding RNAs in myeloma growth, distinguishing characteristics of IgM-MM from Waldenström macroglobulinemia, and identifying BCMA gene alterations as a resistance mechanism against CAR T cell therapy, highlighting the complex genetic landscape of MM.
