The prevalence of obesity is increased in patients with late compared with early onset psoriasis.

Purpose: We compared the clinical and epidemiologic characteristics of early and late onset psoriasis with an emphasis on potential differences in the comorbidities associated with each subtype.

Methods: An observational, multicenter study was performed, and associations between the age at the time of diagnosis and binary comorbidity outcomes were evaluated using multiple logistic regression analysis adjusted for age and other relevant confounders.

Results: An increased prevalence of positive family history, psoriatic arthritis, and depression was observed in patients with early onset psoriasis.