β-Carboline-3-carboxamide Antimalarials: Structure-Activity Relationship, ADME-Tox Studies, and Resistance Profiling.

The development of parasite resistance to both artemisinin derivatives and their partner drugs jeopardizes the effectiveness of the artemisinin combination therapy. Thus, the discovery of new antimalarial drugs, with new mechanisms of action, is urgently needed. We recently disclosed that β-carboline was orally efficacious in -infected mice and that it showed low cross-resistance between susceptible and four different drug-resistant strains.

Microwave-Assisted Hydrothermal Synthesis of Photocatalytic Truncated-Bipyramidal TiO/TiCN Heterostructures Derived from TiCN MXene.

TiO/MXene heterostructure has garnered significant interest as a photocatalyst due to its large surface area and efficient charge carrier separation at the interface. However, current synthesis methods produce TiO without clear crystal faceting and often require complicated postprocessing step, limiting its practical applications. We demonstrate a facile and controlled microwave-assisted hydrothermal synthesis for transforming multilayered TiCN MXene to a truncated-bipyramidal TiO/TiCN heterostructure.

Pyramiding of bacterial blight resistance genes into promising restorer BRRI31R line through marker-assisted backcross breeding and evaluation of agro-morphological and physiochemical characteristics of developed resistant restorer lines.

BRRI31R is one of the Bangladesh's most promising restorer lines due to its abundant pollen producing capacity, strong restoring ability, good combining ability, high outcrossing rate and genetically diverse from cytoplasmic male sterile (CMS) line. But the drawback of this line is that it is highly susceptible to bacterial blight (BB) disease of rice caused by Xanthomonas oryzae pv. oryzae.

Evaluation of Aflatoxins and Heavy Metals Exposure in the Local Feeds of Fish and Shrimp in Bangladesh.

This study aims to comprehensively assess the presence of aflatoxins, pervasive fungal toxins, and heavy metals (lead, chromium, cadmium) in the local feed of fish and shrimp. Forty-eight samples of the fish and shrimp feed were collected from the Dhaka and Sathkhira districts of Bangladesh respectively. Aflatoxins (B1, B2, G1, G2) were analyzed by high-performance liquid chromatography (HPLC) with fluorescence detector, and atomic absorption spectrophotometry (AAS) was used for the heavy metal detection after sample digestion.

Whole genome sequence of denitrifying bacterium strain NGHE31, collected from an eutrophic wetland in Sunamganj, Bangladesh, following the 2017 flash floods.

Here, we report the whole genome sequence of strain NGHE31, isolated from Dekhar Haor, following the 2017 flash flood that resulted in mass die-offs of local wildlife. The predicted genome size is 4,434,670 bp, with 63.97% GC content, 4,035 coding sequences, 3 rRNAs, and 50 tRNAs.

Ambient Processed rGO/TiCNT MXene Thin Film with High Oxidation Stability, Photosensitivity, and Self-Cleaning Potential.

Solution-based processing offers advantages for producing thin films due to scalability, low cost, simplicity, and benignity to the environment. Here, we develop conductive and photoactivated self-cleaning reduced graphene oxide (rGO)/TiCNT MXene thin films spin coating under ambient conditions. The addition of a thin rGO layer on top of TiCNT resulted in up to 45-fold improvement in the environmental stability of the film compared to the bare TiCNT film.

Immunomodulatory Role of Vitamin D on Gut Microbiome in Children.

Vitamin D plays a role in regulating the immune system and can be linked to the alteration of the gut microbiome, which leads to several immunological diseases. This systematic review aims to explore the relationship between Vitamin D and children's gut microbiome, as well as its impact towards the immune system. We have systematically collated relevant studies from different databases concerning changes in the gut microbiome of children from infants to 18 years old associated with Vitamin D and the immunological pathways.

Snapshot multispectral imaging using a diffractive optical network.

Multispectral imaging has been used for numerous applications in e.g., environmental monitoring, aerospace, defense, and biomedicine.

Genome-wide investigation of SnRK2 gene family in two jute species: Corchorus olitorius and Corchorus capsularis.

Background: Sucrose non-fermenting-1 (SNF1)-related protein kinase 2 (SnRK2), a plant-specific serine/threonine kinase family, is associated with metabolic responses, including abscisic acid signaling under biotic and abiotic stresses. So far, no information on a genome-wide investigation and stress-mediated expression profiling of jute SnRK2 is available. Recent whole-genome sequencing of two Corchorus species prompted to identify and characterize this SnRK2 gene family.

Super-resolution image display using diffractive decoders.

High-resolution image projection over a large field of view (FOV) is hindered by the restricted space-bandwidth product (SBP) of wavefront modulators. We report a deep learning-enabled diffractive display based on a jointly trained pair of an electronic encoder and a diffractive decoder to synthesize/project super-resolved images using low-resolution wavefront modulators. The digital encoder rapidly preprocesses the high-resolution images so that their spatial information is encoded into low-resolution patterns, projected via a low SBP wavefront modulator.

Diffractive interconnects: all-optical permutation operation using diffractive networks.

Permutation matrices form an important computational building block frequently used in various fields including, e.g., communications, information security, and data processing.

Evaluation of individual and ensemble probabilistic forecasts of COVID-19 mortality in the United States.

Short-term probabilistic forecasts of the trajectory of the COVID-19 pandemic in the United States have served as a visible and important communication channel between the scientific modeling community and both the general public and decision-makers. Forecasting models provide specific, quantitative, and evaluable predictions that inform short-term decisions such as healthcare staffing needs, school closures, and allocation of medical supplies. Starting in April 2020, the US COVID-19 Forecast Hub (https://covid19forecasthub.

COVID-19 pandemic ramifications on residential Smart homes energy use load profiles.

The COVID-19 pandemic has significantly affected people's behavioral patterns and schedules because of stay-at-home orders and a reduction of social interactions. Therefore, the shape of electrical loads associated with residential buildings has also changed. In this paper, we quantify the changes and perform a detailed analysis on how the load shapes have changed, and we make potential recommendations for utilities to handle peak load and demand response.

A Novel and Robust Approach to Detect Tuberculosis Using Transfer Learning.

Deep learning has emerged as a promising technique for a variety of elements of infectious disease monitoring and detection, including . We built a deep convolutional neural network (CNN) model to assess the generalizability of the deep learning model using a publicly accessible tuberculosis dataset. This study was able to reliably detect tuberculosis (TB) from chest X-ray images by utilizing image preprocessing, data augmentation, and deep learning classification techniques.

International High-Risk Clones Among Extended-Spectrum β-Lactamase-Producing in Dhaka, Bangladesh.

is a major extended-spectrum β-lactamase (ESBL)-producing organism responsible for the rapid spread of antimicrobial resistance (AMR) that has compromised our ability to treat infections. Baseline data on population structure, virulence, and resistance mechanisms in lineages from developing countries such as Bangladesh are lacking. Whole-genome sequencing was performed for 46 ESBL- isolates cultured from patient samples at the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)-Dhaka.

Perturbations in nitric oxide homeostasis promote Arabidopsis disease susceptibility towards Phytophthora parasitica.

Phytophthora species can infect hundreds of different plants, including many important crops, causing a number of agriculturally relevant diseases. A key feature of attempted pathogen infection is the rapid production of the redox active molecule nitric oxide (NO). However, the potential role(s) of NO in plant resistance against Phytophthora is relatively unexplored.

Transporter associated with antigen processing 1 (TAP1) expression and prognostic analysis in breast, lung, liver, and ovarian cancer.

Transporter associated with antigen processing 1 (TAP1) is a transporter protein that represent tumor antigen in the MHC I or HLA complex. Any defect in the TAP1 gene resulting in inadequate tumor tracking. TAP1 influences multidrug resistance (MDR) in human cancer cell lines and hinders the treatment during chemotherapeutic.